GAL3ST1

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.[5][6][7]

GAL3ST1
Identifiers
AliasesGAL3ST1, CST, galactose-3-O-sulfotransferase 1
External IDsOMIM: 602300 MGI: 1858277 HomoloGene: 3574 GeneCards: GAL3ST1
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q12.2Start30,554,635 bp[1]
End30,574,665 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9514

53897

Ensembl

ENSG00000128242

ENSMUSG00000049721

UniProt

Q99999

Q9JHE4

RefSeq (mRNA)

NM_001177691
NM_001177703
NM_016922
NM_001382290
NM_001382291

RefSeq (protein)

NP_001171162
NP_001171174
NP_058618
NP_001369219
NP_001369220

Location (UCSC)Chr 22: 30.55 – 30.57 MbChr 11: 3.98 – 4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000128242 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049721 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  6. Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi:10.1074/jbc.272.8.4864. PMID 9030544.
  7. "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Further reading


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