Grb2 associated binding protein 3

GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. [5]

GAB3
Identifiers
Aliases	GAB3, GRB2 associated binding protein 3
External IDs	OMIM: 300482 MGI: 2387324 HomoloGene: 15417 GeneCards: GAB3
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,675,249 bp[1] End 154,751,583 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 74,966,843 bp[2] End 75,085,458 bp[2]
Orthologs
Species	Human	Mouse
Entrez	139716	210710
Ensembl	ENSG00000160219	ENSMUSG00000032750
UniProt	Q8WWW8	Q8BSM5
RefSeq (mRNA)	NM_001081573 NM_001282283 NM_080612	NM_181584
RefSeq (protein)	NP_001075042 NP_001269212 NP_542179	NP_853615
Location (UCSC)	Chr X: 154.68 – 154.75 Mb	Chr X: 74.97 – 75.09 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.

References

1. GRCh38: Ensembl release 89: ENSG00000160219 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032750 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.

Further reading

• Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G (2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Mol. Cell. Biol. 22 (11): 3744–56. doi:10.1128/mcb.22.11.3744-3756.2002. PMC 133813. PMID 11997510.
• Sliz, Anna; Locker, Kathryn C. S.; Lampe, Kristin; Godarova, Alzbeta; Plas, David R.; Janssen, Edith M.; Jones, Helen; Herr, Andrew B.; Hoebe, Kasper (2019). "Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy". Science Immunology. 4 (38): eaav3866. doi:10.1126/sciimmunol.aav3866. ISSN 2470-9468. PMC 7068803.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.