Grb2 associated binding protein 3
GRB2 associated binding protein 3 is a protein that in humans is encoded by the GAB3 gene. [5]
| GAB3 | |||||||||||||||||||||||||
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| Aliases | GAB3, GRB2 associated binding protein 3 | ||||||||||||||||||||||||
| External IDs | OMIM: 300482 MGI: 2387324 HomoloGene: 15417 GeneCards: GAB3 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr X: 154.68 – 154.75 Mb | Chr X: 74.97 – 75.09 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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Function
This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants.
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References
- GRCh38: Ensembl release 89: ENSG00000160219 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000032750 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "GAB3 GRB2 associated binding protein 3 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 2019-08-03.
Further reading
- Bourgin C, Bourette RP, Arnaud S, Liu Y, Rohrschneider LR, Mouchiroud G (2002). "Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation". Mol. Cell. Biol. 22 (11): 3744–56. doi:10.1128/mcb.22.11.3744-3756.2002. PMC 133813. PMID 11997510.
- Sliz, Anna; Locker, Kathryn C. S.; Lampe, Kristin; Godarova, Alzbeta; Plas, David R.; Janssen, Edith M.; Jones, Helen; Herr, Andrew B.; Hoebe, Kasper (2019). "Gab3 is required for IL-2– and IL-15–induced NK cell expansion and limits trophoblast invasion during pregnancy". Science Immunology. 4 (38): eaav3866. doi:10.1126/sciimmunol.aav3866. ISSN 2470-9468. PMC 7068803.
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