Günther K.H. Zupanc

Günther K.H. Zupanc (born 20 October 1958) is a neurobiologist, researcher, university teacher, book author, journal editor, and educational reformer. He is Professor in the Department of Biology at Northeastern University in Boston, Massachusetts.

Günther K.H. Zupanc in 2015

Education

Günther Zupanc was born in Augsburg in (then) West-Germany. He graduated in Biology and Physics from the University of Regensburg (Germany) with degrees equivalent to Bachelor’s and master's degrees. He received his Ph.D. in Neurosciences from the University of California, San Diego (1990), and he was awarded the habilitation (Dr. rer. nat. habil.) in Animal Physiology from the University of Tübingen (Germany) (1995).[1][2]

Journalistic career

Before enrolling in college, Zupanc worked as a journalist for the Münchner Merkur, a major daily newspaper in Munich, Germany, where he specialized in science writing. He also published numerous science articles in other newspapers and magazines. For one of his articles, he was awarded first prize in the contest Reporter der Wissenschaft as Germany’s best young science writer in 1980.[3][4]

Academic career

Günther Zupanc was Research Assistant and Research Scientist at the Scripps Institution of Oceanography in La Jolla, California (1987–92), Junior Group Leader at the Max Planck Institute for Developmental Biology in Tübingen, Germany (1992–97), Senior Lecturer (equivalent to Associate Professor) at the University of Manchester, U.K. (1997–2002), and Professor at the International University Bremen (now Jacobs University Bremen) (2002–09). Since 2009 he has been Professor at Northeastern University in Boston, Massachusetts, where he also served as Chair of the Department of Biology (2009–12). Zupanc was Visiting Professor at the University of Ottawa, Canada (1994–97) and Visiting Scholar at the University of California, San Diego, the University of Chicago, the Max Planck Institute for Behavioral Physiology, the Salk Institute for Biological Studies, the Scripps Research Institute, Tufts University, and Jacobs University Bremen.

Research

Zupanc has made important contributions to several disciplines within biology, including neuroethology, neuroanatomy, neuroendocrinology, and developmental neurobiology.

In his early work, he showed that seasonal changes in specific behavioral patterns are paralleled by pronounced alterations in the structure of brain neurons that control these behaviors.[5]

His laboratory has extensively studied the behavior of weakly electric fish. Among others, these investigations led to the discovery of a novel behavioral pattern, the 'echo response'.[6]

As part of his efforts to establish the brown ghost knifefish (Apteronotus leptorhynchus) as a powerful model organisms for the study of behavior and neural plasticity, his laboratory performed (in collaboration with the group of Jeffrey N. Agar of the Department of Chemistry and Chemical Biology at Northeastern University) a de novo assembly, annotation, and proteomics validation of the central nervous system transcriptome of this species.[7]

Using the electric organ discharge of weakly electric fish as a neuroethological model system, Zupanc and his team were the first to employ a proteomics approach for large-scale identification of proteins involved in the development of a sexual dimorphism in behavior.[8] The results of this research have implications beyond this study, suggesting that astrocytes play an important role in the regulation of the activity of neural oscillators, including those that control a sexually dimorphic behavior.[9]

In the field of neuroendocrinology, Zupanc and his collaborators succeeded in the cloning and pharmacological characterization of the first non-mammalian somatostatin neuropeptide receptor.[10]

His laboratory developed a novel in vitro technique to trace neural connections in the brain.[11] This approach led to the discovery of numerous previously unknown connections in the brain of teleost fish.

Since the early 1990s, Zupanc’s research group has pioneered the study of adult neurogenesis (the generation of new neurons in the adult central nervous system) in teleosts. He and his wife Marianne M. Zupanc introduced labeling of mitotic cells with 5-bromo-2'-deoxyuridine (BrdU) to research on adult neurogenesis.[12] Since then, this method has been used by numerous investigators working in this area. His research group performed the first complete mapping of proliferation zones in the adult brain of any vertebrate species (1995),[13] and he and his associates introduced zebrafish (2005)[14] and tilapia (2012)[15] as model systems to study adult neurogenesis. To provide an explanation for the biological function of adult neurogenesis, he formulated the 'matching hypothesis.' According to this hypothesis, neurogenesis in the adult central nervous system is the result of the continuous generation of new muscle fibers and sensory receptor cells in the periphery.[16][17][18] To maintain a constant ratio between the peripheral motor and sensory elements on the one side, and the central elements on the other, any numerical change in the periphery prompts a corresponding numerical alteration (production or loss of neurons) in the central nervous system.

He and his team also demonstrated that the continued generation of new neurons in the adult central nervous system of teleost fish is closely linked to the enormous potential of this taxon to regenerate nervous tissue and to recover behavioral function after brain lesions and spinal cord injury.[19][20][21] By employing a proteomics approach, Zupanc and his associates performed the first large-scale analysis in teleost fish of changes in global protein expression after brain trauma. As part of this effort, the team succeeded in the identification of a large number of proteins potentially involved in the regeneration of nervous tissue.[22][23]

In an expansion of their research on adult neurogenesis, the laboratory of Zupanc discovered the first vertebrate organism that lacks any of the hallmarks of brain senescence common to humans and all mammalian species examined thus far.[24] In contrast to the latter, brown ghost knifefish (Apteronotus leptorhynchus) do not exhibit any significant age-related decline in stem/progenitor cell proliferation, neuronal and glial differentiation, or long-term survival of newly generated cells. The availability of this first vertebrate model of ‘negligible senescence’ provides unprecedented opportunities for a better understanding of the biology of aging and of the cellular mechanisms that protect brains from senescing.

As the first investigator in the field of adult neurogenesis, Zupanc and his laboratory succeeded in generating three-dimensional, high-resolution maps of adult stem cells and their progeny, as well as molecular profiles of these cells, in the spinal cord.[25] This work led to the development of a novel mapping approach (‘statistical mapping’), which enables researchers to produce global maps of central nervous system structures with cellular resolution. By integrating the big data set collected through such experimental work, Zupanc and his collaborators Iulian Ilieş and Rifat Sipahi (Department of Mechanical & Industrial Engineering, Northeastern University) succeeded in building the first mathematical model of tissue growth in the spinal cord.[26] This model provides an important theoretical framework for better understanding tissue growth in the intact and the regenerating central nervous system.

In collaboration with Rifat Sipahi, Zupanc also constructed computational models that simulate normal and tumorous tissue growth in vitro.[27][28] Using this approach, the team has provided a theoretical explanation for the seemingly paradoxical effect that in lymphoma and prostate cancer cell-death-inducing chemotherapy sometimes induces tumors, instead of suppressing them.[29]

A characteristic feature of the research of Günther Zupanc is the application of a multidisciplinary approach — the techniques and concepts used in his investigations are taken from a wide range of disciplines, including molecular biology, cell biology, neuroanatomy, neurophysiology, computational neurosciences, behavioral neurobiology, analytical chemistry, biophysics, and mathematical modeling.

Editor of journals
Behavioral Neurobiology: An Integrative Approach, Third Edition

Zupanc was Editor of the Journal of Zoology (2007–11), and he has been Editor of the Journal of Comparative Physiology A since 2008. He has also edited special issues of several scientific journals, including Adult Neurogenesis: A Comparative Approach for Brain, Behavior and Evolution, Electric Fish: Model Systems for Neurobiology and Integrative and Comparative Neurobiology: Papers in Memoriam of Theodore H. Bullock (1915-2005) for Journal of Comparative Physiology A, Towards a Comparative Understanding of Adult Neurogenesis (jointly with Luca Bonfanti and Ferdinando Rossi) for European Journal of Neuroscience, and Adult Neural Stem Cells in Development, Regeneration, and Aging (jointly with James Monaghan and David L. Stocum) for Developmental Neurobiology. Zupanc served on the Editorial Advisory Boards of the journals Brain, Behavior and Evolution, Journal of Comparative Physiology A, and Journal of Neurorestoratology. He is currently a member of the Editorial Boards of Regenerative Medicine and Developmental Neurobiology.

Book author

Günther K.H. Zupanc published his first book, Fische und ihr Verhalten (1982),[30] while he was still an undergraduate student. This book appeared subsequently in an English edition under the title Fish and Their Behavior[31] and became a bestseller. Zupanc is Editor of Praktische Verhaltensbiologie (1988),[32] a laboratory manual used widely in German-speaking countries in biology education. His book Behavioral Neurobiology: An Integrative Approach (2004; third edition: 2019)[33] is the most frequently adopted text in teaching behavioral neurobiology classes in the world. In a review by the journal Integrative and Comparative Biology, it has been praised as “a milestone in the neuroethological literature”.[34]


Educational reformer
Günther Zupanc with German minister Svenja Schulze in 2015

Zupanc was among the founding faculty of the International University Bremen (now Jacobs University Bremen), a unique private international university that combines features of the European Higher Education systems with the U.S. American Higher Education system. He played a leading role in defining and establishing the biology degree program at this institution. In 2009, this program received the top ranking of all universities evaluated by the Center for Higher Education Development (CHE).[35] Zupanc has also published extensively on history of science,[36][37] as well as on science policy issues, including biology teaching,[38] online education,[39] internationalization of higher education,[40] integration of undergraduate students into research,[41] student fellowships,[42] student debt,[43] privatization of higher education,[44] research assessment,[45] university rankings,[46] ethics of part-time teaching contracts,[47] and collaboration in the competitive world of science.[48] Günther Zupanc is frequently sought as a speaker and advisor on science and higher education policy.[49]






Personal life

Günther K.H. Zupanc is married to Dr. Marianne M. Zupanc, a microbiologist and high school teacher, with whom he has three children, Frederick, Christina, and Daniel.

Notes
  1. "Oxford University Press | Ancillary Resource Centre | Zupanc: Behavioral Neurobiology 3e - Author Biography". www.oup.com. Retrieved 29 June 2020.
  2. "Oxford University Press | Ancillary Resource Centre | Zupanc: Behavioral Neurobiology 3e - Günther K.H. Zupanc: Embrace the twists and turns, and never lose sight of your dreams". www.oup.com. Retrieved 29 June 2020.
  3. "Reporter der Wissenschaft". Die Zeit. 16 May 1980. Retrieved 2 November 2016.
  4. "I. Preis beim Wettbewerb "Reporter der Wissenschaft": Seine zweite Heimat heißt "Neritica"". Die Zeit. 16 May 1980. Retrieved 2 November 2016.
  5. Zupanc, G.K.H.; Heiligenberg, W.F. (1989). "Sexual maturity-dependent changes in neuronal morphology in the prepacemaker nucleus of adult weakly electric knifefish, Eigenmannia". Journal of Neuroscience. 9: 3816–3827. doi:10.1523/JNEUROSCI.09-11-03816.1989. PMID 2479726.
  6. Zupanc, G.K.H.; Sîrbulescu, R.F.; Nichols, A.; Ilies, I.V. (2006). "Electric interactions through chirping behavior in the weakly electric fish, Apteronotus leptorhynchus". Journal of Comparative Physiology A. 192 (2): 159–173. doi:10.1007/s00359-005-0058-5. PMID 16247622.
  7. Salisbury, G.J.P.; Sîrbulescu, R.F.; Moran, B.; Auclair, J.R.; Zupanc, G.K.H.; Agar, J.N. (2015). "The central nervous system transcriptome of the weakly electric brown ghost knifefish (Apteronotus leptorhynchus): de novo assembly, annotation, and proteomics validation". BMC Genomics. 16: 166. doi:10.1186/s12864-015-1354-2. PMC 4424500. PMID 25879418.
  8. Zupanc, G.K.H.; Ilieş, I.; Sîrbulescu, R.F.; Zupanc, M.M. (2014). "Large-scale identification of proteins involved in the development of a sexually dimorphic behavior". Journal of Neurophysiology. 111 (8): 1646–1654. doi:10.1152/jn.00750.2013. PMID 24478160.
  9. Zupanc, G.K.H. (2020). "Development of a sexual dimorphism in a central pattern generator driving a rhythmic behavior: the role of glia-mediated potassium buffering in the pacemaker nucleus of the weakly electric fish Apteronotus leptorhynchus". Developmental Neurobiology. 80 (1–2): 6–15. doi:10.1002/dneu.22736. PMID 32090501.
  10. Zupanc, G.K.H.; Siehler, S.; Jones, E.M.C.; Seuwen, K.; Furuta, H.; Hoyer, D.; Yano, H. (1999). "Molecular cloning and pharmacological characterization of a somatostatin receptor subtype in the gymnotiform fish Apteronotus albifrons". General and Comparative Endocrinology. 115 (3): 333–345. doi:10.1006/gcen.1999.7316. PMID 10480984.
  11. Zupanc, G.K.H. (1998). "An in vitro technique for tracing neuronal connections in the teleost brain". Brain Research Protocols. 3: 37–51. doi:10.1016/s1385-299x(98)00019-1.
  12. Zupanc, G.K.H.; Zupanc, M.M. (1992). "Birth and migration of neurons in the central posterior/prepacemaker nucleus during adulthood in weakly electric knifefish, Eigenmannia sp". Proceedings of the National Academy of Sciences of the United States of America. 89 (20): 9539–9543. doi:10.1073/pnas.89.20.9539. PMC 50167. PMID 1409663.
  13. Zupanc, G.K.H.; Horschke, I. (1995). "Proliferation zones in the brain of adult gymnotiform fish: a quantitative mapping study". Journal of Comparative Neurology. 353 (2): 213–233. doi:10.1002/cne.903530205. PMID 7745132.
  14. Zupanc, G.K.H.; Hinsch, K.; Gage, F.H. (2005). "Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult brain of zebrafish". Journal of Comparative Neurology. 488 (3): 290–319. doi:10.1002/cne.20571. PMID 15952170.
  15. Teles, M.C.; Sîrbulescu, R.F.; Wellbrock, U.M.; Oliveira, R.F.; Zupanc, G.K.H. (2012). "Adult neurogenesis in the brain of the Mozambique Tilapia, Oreochromis mossambicus". Journal of Comparative Physiology A. 198 (6): 427–449. doi:10.1007/s00359-012-0721-6.
  16. Zupanc, G.K.H. (2001). "Adult neurogenesis and neuronal regeneration in teleost fish". Brain, Behavior and Evolution. 58 (5): 250–275. doi:10.1159/000057569. PMID 11978945.
  17. Zupanc, G.K.H. (2006). "Neurogenesis and neuronal regeneration in the adult fish brain". Journal of Comparative Physiology A. 192 (6): 649–670. doi:10.1007/s00359-006-0104-y. PMID 16463148.
  18. Zupanc, G.K.H. (2008). "Adult neurogenesis and neuronal regeneration in the brain of teleost fish". Journal of Physiology (Paris). 102 (4–6): 357–373. doi:10.1016/j.jphysparis.2008.10.007. PMID 18984045.
  19. Sîrbulescu, R.F.; Zupanc, G.K.H. (2011). "Spinal cord repair in regeneration-competent vertebrates: adult teleost fish as a model system". Brain Research Reviews. 67 (1–2): 73–93. doi:10.1016/j.brainresrev.2010.11.001. PMID 21059372.
  20. Zupanc, G.K.H.; Sîrbulescu, R.F. (2011). "Adult neurogenesis and neuronal regeneration in the central nervous system of teleost fish". European Journal of Neuroscience. 34 (6): 917–929. doi:10.1111/j.1460-9568.2011.07854.x.
  21. "Archived copy". Archived from the original on 2011-04-08. Retrieved 2011-12-07.CS1 maint: archived copy as title (link)
  22. Zupanc, M.M.; Wellbrock, U.M.; Zupanc, G.K.H. (2006). "Proteome analysis identifies novel protein candidates involved in regeneration of the cerebellum of teleost fish". Proteomics. 6 (2): 677–696. doi:10.1002/pmic.200500167. PMID 16372261.
  23. Ilieş, I.; Zupanc, M.M.; Zupanc, G.K.H. (2012). "Proteome analysis reveals protein candidates involved in early stages of brain regeneration in teleost fish". Neuroscience. 219: 302–313. doi:10.1016/j.neuroscience.2012.05.028. PMID 22659563.
  24. Traniello, I.M.; Sîrbulescu, R.F.; Ilieş, I.; Zupanc, G.K.H. (2014). "Age-related changes in stem cell dynamics, neurogenesis, apoptosis, and gliosis in the adult brain: a novel teleost fish model of negligible senescence". Developmental Neurobiology. 74 (5): 514–530. doi:10.1002/dneu.22145. PMID 24293183.
  25. Sîrbulescu, R.F.; Ilieş, I.; Meyer, A.; Zupanc, G.K.H. (2017). "Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: a spatiotemporal statistical mapping analysis in a teleost model of indeterminate growth". Developmental Neurobiology. 77 (11): 1269–1307. doi:10.1002/dneu.22511. PMID 28707354.
  26. Ilieş, I.; Sipahi, R.; Zupanc, G.K.H. (2017). "Growth of adult spinal cord in knifefish: development and parametrization of a distributed model". Journal of Theoretical Biology. 437: 101–114. doi:10.1016/j.jtbi.2017.10.012. PMID 29031516.
  27. Sipahi, R.; Zupanc, G.K.H. (2018). "Stochastic cellular automata model of neurosphere growth: roles of proliferative potential, contact inhibition, cell death, and phagocytosis". Journal of Theoretical Biology. 445: 151–165. doi:10.1016/j.jtbi.2018.02.025. PMID 29477556.
  28. Zupanc, G.K.H.; Zupanc, F.B. (2019). "Stochastic cellular automata model of tumorous neurosphere growth: roles of developmental maturity and cell death". Journal of Theoretical Biology. 467: 100-110. doi:10.1016/j.jtbi.2019.01.028. PMID 30707973.
  29. Castañón, Laura (25 February 2019). "Researchers may have discovered why some tumors grow back aggressively after radiation, chemotherapy". MedicalExpress. Retrieved 28 June 2020.
  30. Zupanc, G.K.H. "Fische und ihr Verhalten. Die Erforschung der geheimnisvollen Welt unter Wasser. Mit einem Geleitwort von Prof. Dr. Arthur Davis Hasler, vorm. Direktor des Laboratory of Limnology der Universität Wisconsin in Madison (USA). 182 pp., ISBN 3-923880-11-1. Tetra Verlag, Melle (1982)
  31. Zupanc, G.K.H. "Fish and Their Behavior. How Fishes Live - Specially Written for Aquarists. Preface by Dr. Dr. h.c. Dr. h.c. Arthur Davis Hasler, Professor Emeritus at the University of Wisconsin in Madison (U.S.A.). 187 pp. 2nd edition. ISBN 3-923880-19-7. Tetra-Press, Melle (1988)
  32. Zupanc, G.K.H. (Editor): Praktische Verhaltensbiologie. Mit Beiträgen von Helmut Altner, Wilhelm Beier, Christiane Buchholtz, Martin Dambach, Benno Darnhofer-Demar, Klaus Dumpert, Dierk Franck, Reinhard Gerecke, Hartmut Greven, Volker Hahn, Ernst Kullmann, Jürg Lamprecht, Martin Lindauer, Hans Machemer, Ulrich Maschwitz, Marliese Müller, Rüdiger Schröpfer, Roland Sossinka und Günther K.H. Zupanc. Series: Pareys Studientexte 61. 274 pp. ISBN 3-489-62936-1. Verlag Paul Parey, Berlin/Hamburg (1988)
  33. Zupanc, G.K.H. "Behavioral Neurobiology: An Integrative Approach. Foreword by Theodore H. Bullock. Third Edition. ISBN 978-0-19-873872-5. Oxford University Press, Oxford/New York (2019)
  34. https://academic.oup.com/icb/article/50/5/911/646425
  35. "Jacobs University - Inspiration is a Place". www.jacobs-university.de. Retrieved 2 November 2016.
  36. Zupanc, G.K.H.; Bullock, T.H. (2006). "Walter Heiligenberg: the jamming avoidance response and beyond". Journal of Comparative Physiology A. 192 (6): 561–572. doi:10.1007/s00359-006-0098-5. PMID 16645884.
  37. Zupanc, G.K.H. (2006). "Theodore H. Bullock (1915-2005) Trailblazer in neurobiology". Nature. 439 (7074): 280. doi:10.1038/439280a. PMID 16421559.
  38. Zupanc, G. K. H. (2008). "Teaching zoology in the twenty-first century: old challenges and new opportunities". Journal of Zoology. 274 (2): 105–106. doi:10.1111/j.1469-7998.2007.00400.x.
  39. Zupanc, G.K.H.: Bildung übers Internet: Billige Mittelmäßigkeit für viele, teure Exzellenz für wenige? Neue Gesellschaft/Frankfurter Hefte No. 6, 50-53 (2013)
  40. Zupanc, G.K.H.; Zupanc, M.M. (2009). "Global revolutions in higher education: the international schools' perspective". The International Schools Journal. 29 (1): 50–59.
  41. Zupanc, G.K.H. (2012). "Undergraduate research and inquiry-based learning: the revitalization of the Humboldtian ideals". Bioscience Education. 19: 1–11. doi:10.11120/beej.2012.19000011.
  42. http://library.fes.de/pdf-files/studienfoerderung/07496.pdf
  43. Zupanc, G.K.H. "Amerika studiert sich in den Ruin: In den USA steigen die Gebühren an vielen Hochschulen exorbitant ˗ darunter leidet das ganze Land. Süddeutsche Zeitung 23, 13, 28 January 2013 (2013)
  44. Zupanc, G.K.H. "Ende eines Traums. Süddeutsche Zeitung No. 4, 13, 7 January 2014 (2014)
  45. Zupanc, G. K. H. (2014). "Impact beyond the impact factor". Journal of Comparative Physiology A. 200 (2): 113–116. doi:10.1007/s00359-013-0863-1. PMID 24264238.
  46. Zupanc, G.K.H. "Überraschend Spitze. Süddeutsche Zeitung No. 264, 15, 17 November 2014 (2014)
  47. http://www.journalistenetage.de/journalist/wp-content/uploads/2015/10/Vorbild-USA.pdf
  48. Zupanc, G.K.H. (2015). "Collaboration in the competitive world of science: lessons to be learned from William T. Keeton". Journal of Comparative Physiology A. 201 (10): 957–960. doi:10.1007/s00359-015-1013-8. PMID 26160232.
  49. Zupanc, Günther. "Karriere-Irrwege des Deutschen Wissenschaftssystems. 7. Hochschulpolitisches Forum der Hans-Böckler-Stiftung 2015: "Gute Arbeit an Hochschulen – die Basis für ein gutes Studium"". Retrieved 29 June 2020.
gollark: Not a fractal. Probably. I forgot the technical definition.
gollark: ↑
gollark: You said, yes.
gollark: Oh, I finally managed to understand what you're asking, I think.
gollark: Evolution is actually very slow, in general.
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