FRAT2

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.[5][6][7]

FRAT2
Identifiers
Aliases	FRAT2, WNT signaling pathway regulator, FRAT-2, FRAT regulator of WNT signaling pathway 2
External IDs	OMIM: 605006 MGI: 2673967 HomoloGene: 8095 GeneCards: FRAT2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.1 Start 97,332,497 bp[1] End 97,334,729 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 35.33 cM Start 41,845,972 bp[2] End 41,848,132 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • molecular function Cellular component • cytosol • cellular component • cytoplasm Biological process • multicellular organism development • cellular proliferation • Wnt signaling pathway • beta-catenin destruction complex disassembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23401	212398
Ensembl	ENSG00000181274	ENSMUSG00000047604
UniProt	O75474	Q8K025
RefSeq (mRNA)	NM_012083	NM_177603
RefSeq (protein)	NP_036215	NP_808271
Location (UCSC)	Chr 10: 97.33 – 97.33 Mb	Chr 19: 41.85 – 41.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000181274 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047604 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432.
6. Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732.
7. "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bax B, Carter PS, Lewis C, et al. (2002). "The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation". Structure. 9 (12): 1143–52. doi:10.1016/S0969-2126(01)00679-7. PMID 11738041.
• Freemantle SJ, Portland HB, Ewings K, et al. (2002). "Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2". Gene. 291 (1–2): 17–27. doi:10.1016/S0378-1119(02)00594-2. PMID 12095675.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stoothoff WH, Cho JH, McDonald RP, Johnson GV (2005). "FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation". J. Biol. Chem. 280 (1): 270–6. doi:10.1074/jbc.M410061200. PMID 15522877.