FOXO6

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[5]

FOXO6
Identifiers
Aliases	FOXO6, forkhead box O6
External IDs	OMIM: 611457 MGI: 2676586 HomoloGene: 82395 GeneCards: FOXO6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 41,361,922 bp[1] End 41,383,590 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.1 Start 120,267,079 bp[2] End 120,287,349 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • sequence-specific DNA binding Cellular component • cell nucleus Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	100132074	329934
Ensembl	ENSG00000204060 ENSG00000281518	ENSMUSG00000052135
UniProt	A0A1X9RU27	Q70KY4
RefSeq (mRNA)	NM_001291281	NM_194060
RefSeq (protein)	NP_001278210	NP_918949
Location (UCSC)	Chr 1: 41.36 – 41.38 Mb	Chr 4: 120.27 – 120.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[6]

References

1. ENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052135 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Forkhead box O6".
6. Lee S, Dong HH (2017). "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology. 233 (2): R67–R79. doi:10.1530/JOE-17-0002. PMC 5480241. PMID 28213398.

Further reading

• Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP (September 2003). "FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics". The Journal of Biological Chemistry. 278 (38): 35959–67. doi:10.1074/jbc.M302804200. PMID 12857750.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Kleindorp R, Flachsbart F, Puca AA, Malovini A, Schreiber S, Nebel A (August 2011). "Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans". Aging Cell. 10 (4): 622–8. doi:10.1111/j.1474-9726.2011.00698.x. PMID 21388494.
• Tzivion G, Dobson M, Ramakrishnan G (November 2011). "FoxO transcription factors; Regulation by AKT and 14-3-3 proteins". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813 (11): 1938–45. doi:10.1016/j.bbamcr.2011.06.002. PMID 21708191.
• Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH (November 2011). "FoxO6 integrates insulin signaling with gluconeogenesis in the liver". Diabetes. 60 (11): 2763–74. doi:10.2337/db11-0548. PMC 3198083. PMID 21940782.
• Kim DH, Zhang T, Lee S, Dong HH (September 2013). "FoxO6 in glucose metabolism (FoxO6)". Journal of Diabetes. 5 (3): 233–40. doi:10.1111/1753-0407.12027. PMC 3657578. PMID 23324123.
• Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y, Cheng-hong P (July 2013). "FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc". FEBS Letters. 587 (14): 2105–11. doi:10.1016/j.febslet.2013.05.027. PMID 23714368.