FMNL2

Formin-like protein 2 is a protein that in humans is encoded by the FMNL2 gene.[5][6]

FMNL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YC7
Identifiers
Aliases	FMNL2, FHOD2, formin like 2
External IDs	OMIM: 616285 MGI: 1918659 HomoloGene: 70871 GeneCards: FMNL2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q23.3 Start 152,335,174 bp[1] End 152,649,826 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 52,857,860 bp[2] End 53,133,804 bp[2]
Gene ontology Molecular function • Rho GTPase binding • actin binding • cadherin binding • GTPase activating protein binding Cellular component • cytoplasm • cytosol Biological process • regulation of cell morphogenesis • GO:0033109 cortical actin cytoskeleton organization • cytoskeleton organization • actin cytoskeleton organization • cellular component organization • regulation of cell shape Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114793	71409
Ensembl	ENSG00000157827	ENSMUSG00000036053
UniProt	Q96PY5	A2APV2
RefSeq (mRNA)	NM_001004417 NM_001004421 NM_001004422 NM_052905	NM_172409
RefSeq (protein)	NP_443137	NP_765997
Location (UCSC)	Chr 2: 152.34 – 152.65 Mb	Chr 2: 52.86 – 53.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Expression

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described.[5] The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2[7]) is regulated through autoinhibition, and may become activated through Rho proteins.[8] The FMNL2 gene is expressed in multiple human tissues.[9]

Function

Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.[5]

Clinical significance

FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.[10]

See also

• FMNL1
• FMNL3

References

1. GRCh38: Ensembl release 89: ENSG00000157827 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036053 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FMNL2 formin-like 2".
6. Katoh M, Katoh M (May 2003). "Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico". Int. J. Oncol. 22 (5): 1161–8. doi:10.3892/ijo.22.5.1161. PMID 12684686.
7. "formin-like protein 2 [Homo sapiens]" (NCBI Reference Sequence: NP_443137.2). National Center for Biotechnology Information, U.S. National Library of Medicine.
8. Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R (April 2010). "Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC". Oncogene. 29 (16): 2441–8. doi:10.1038/onc.2009.515. PMID 20101212.
9. Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O (2010). "Characterization of Diaphanous-related formin FMNL2 in human tissues". BMC Cell Biol. 11: 55. doi:10.1186/1471-2121-11-55. PMC 2912821. PMID 20633255.
10. Zhu XL, Liang L, Ding YQ (November 2008). "Overexpression of FMNL2 is closely related to metastasis of colorectal cancer". Int J Colorectal Dis. 23 (11): 1041–7. doi:10.1007/s00384-008-0520-2. PMID 18665374.