FIBP

Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene.[5][6]

FIBP
Identifiers
Aliases	FIBP, FGFIBP-1, FGF1 intracellular binding protein, TROFAS
External IDs	OMIM: 608296 MGI: 1926233 HomoloGene: 3106 GeneCards: FIBP
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,883,741 bp[1] End 65,888,539 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 5,460,615 bp[2] End 5,465,051 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • fibroblast growth factor binding Cellular component • extracellular exosome • membrane • mitochondrion • cell nucleus • endomembrane system • nuclear speck Biological process • fibroblast growth factor receptor signaling pathway • platelet aggregation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9158	58249
Ensembl	ENSG00000172500	ENSMUSG00000024911
UniProt	O43427	Q9JI19
RefSeq (mRNA)	NM_004214 NM_198897	NM_001253832 NM_021438
RefSeq (protein)	NP_004205 NP_942600	NP_001240761 NP_067413
Location (UCSC)	Chr 11: 65.88 – 65.89 Mb	Chr 19: 5.46 – 5.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene.[6]

Interactions

FIBP has been shown to interact with FGF1.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000172500 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024911 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kolpakova, E; Wiedłocha, A; Stenmark, H; Klingenberg, O; Faines, PO; Olsnes, S (15 November 1998). "Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor". Biochem. J. 336 (1): 213–22. doi:10.1042/bj3360213. PMC 1219860. PMID 9806903.
6. "Entrez Gene: FIBP fibroblast growth factor (acidic) intracellular binding protein".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kolpakova E, Frengen E, Stokke T, Olsnes S (2000). "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein". Biochem. J. 352 (3): 629–35. doi:10.1042/0264-6021:3520629. PMC 1221498. PMID 11104667.
• Tassi E, Al-Attar A, Aigner A, Swift MR, McDonnell K, Karavanov A, Wellstein A (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
• Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002). "Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity". EMBO J. 21 (15): 4058–69. doi:10.1093/emboj/cdf402. PMC 126148. PMID 12145206.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.