FGFR1OP

FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[5][6][7]

CEP43
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D68
Identifiers
Aliases	CEP43, FOP, FGFR1 oncogene partner, centrosomal protein 43, FGFR1OP
External IDs	OMIM: 605392 MGI: 1922546 HomoloGene: 5116 GeneCards: CEP43
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q27 Start 166,999,317 bp[1] End 167,094,789 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A1 Start 8,165,501 bp[2] End 8,196,804 bp[2]
Gene ontology Molecular function • protein homodimerization activity • protein tyrosine kinase inhibitor activity • GO:0001948 protein binding • protein tyrosine kinase activity • protein kinase binding Cellular component • cytoplasm • cytosol • centrosome • microtubule organizing center • perinuclear region of cytoplasm • cytoskeleton • cell nucleus • centriole • cell projection Biological process • negative regulation of protein kinase activity • positive regulation of cell migration • positive regulation of cell growth • microtubule anchoring • G2/M transition of mitotic cell cycle • positive regulation of cell proliferation • peptidyl-tyrosine phosphorylation • negative regulation of protein tyrosine kinase activity • ciliary basal body docking • regulation of G2/M transition of mitotic cell cycle • cell projection organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11116	75296
Ensembl	ENSG00000213066	ENSMUSG00000069135
UniProt	O95684	Q66JX5
RefSeq (mRNA)	NM_194429 NM_001278690 NM_007045	NM_001197046 NM_201230
RefSeq (protein)	NP_001265619 NP_008976 NP_919410	NP_001183975 NP_957682
Location (UCSC)	Chr 6: 167 – 167.09 Mb	Chr 17: 8.17 – 8.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000213066 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000069135 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Popovici C, Zhang B, Grégoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pébusque MJ (February 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.
6. Reither A, Hehlmann R, Goldman JM, Cross NC (April 1999). "[The 8p11 myeloproliferative syndrome]". Medizinische Klinik. 94 (4): 207–10. PMID 10373756.
7. "Entrez Gene: FGFR1OP FGFR1 oncogene partner".

Further reading

• Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pébusque MJ (December 2001). "8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways". Molecular and Cellular Biology. 21 (23): 8129–42. doi:10.1128/MCB.21.23.8129-8142.2001. PMC 99978. PMID 11689702.
• Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pébusque MJ (January 2004). "FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice". Blood. 103 (1): 309–12. doi:10.1182/blood-2003-05-1690. PMID 12969958.
• Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Yan X, Habedanck R, Nigg EA (February 2006). "A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring". Molecular Biology of the Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
• Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA (June 2006). "Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization". Journal of Molecular Biology. 359 (4): 863–75. doi:10.1016/j.jmb.2006.03.070. PMID 16690081.
• Mano Y, Takahashi K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y (December 2007). "Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer". Cancer Science. 98 (12): 1902–13. doi:10.1111/j.1349-7006.2007.00610.x. PMID 17888034.

External links

• Media related to FGFR1OP at Wikimedia Commons