FGFBP1

FGFBP1
Identifiers
Aliases	FGFBP1, FGF-BP, FGF-BP1, FGFBP, FGFBP-1, HBP17, fibroblast growth factor binding protein 1
External IDs	OMIM: 607737 MGI: 1096350 HomoloGene: 3766 GeneCards: FGFBP1
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	15,938,740 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	43,981,779 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• fibroblast growth factor binding; • heparin binding; • GO:0001948 protein binding; • growth factor binding;
Cellular component	• extracellular region; • cell surface; • cell membrane; • membrane; • extracellular;
Biological process	• positive regulation of fibroblast growth factor receptor signaling pathway; • fibroblast growth factor receptor signaling pathway; • signal transduction; • positive regulation of cell proliferation; • negative regulation of cell proliferation; • cell-cell signaling; • positive regulation of cell migration involved in sprouting angiogenesis; • positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9982
	14181
	ENSG00000137440
	ENSMUSG00000048373
	Q14512
	O70514
	NM_005130
	NM_001271616; NM_008009
	NP_005121
	NP_001258545; NP_032035
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.[5][6][7]

FGFBP1, or HBP17, binds to both acidic (FGF1; MIM 131220) and basic (FGF2; MIM 134920) fibroblast growth factors in a reversible manner. It also binds to perlecan (HSPG2; MIM 142461).[supplied by OMIM][7]

Interactions

FGFBP1 has been shown to interaction with Perlecan.[5]

gollark: And being a laptop, there's an "embedded controller" running the fans and whatever, and maybe even a computer thing managing the battery.

gollark: As well as that, the dedicated GPU is arguably a "computer" too, and it has at least one microcontroller on it for various things. Also, the internal keyboard and camera are connected over USB, which means they probably have their own microcontrollers.

gollark: I don't have one of those, but yes.

gollark: It has a WiFi card, obviously, which has yet another computer in it for running... whatever WiFi cards do...

gollark: Graphics Microcontroller and HEVC Microcontroller, they're a weird implementation detail of recent Intel GPUs.

References

GRCh38: Ensembl release 89: ENSG00000137440 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000048373 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.
Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. PMID 1885605.
"Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

Abuharbeid S, Czubayko F, Aigner A (2006). "The fibroblast growth factor-binding protein FGF-BP". Int. J. Biochem. Cell Biol. 38 (9): 1463–8. doi:10.1016/j.biocel.2005.10.017. PMID 16324873.
Lange LG, Sytkowski AJ, Vallee BL (1976). "Human liver alcohol dehydrogenase: purification, composition, and catalytic features". Biochemistry. 15 (21): 4687–93. doi:10.1021/bi00666a023. PMID 9982.
Czubayko F, Liaudet-Coopman ED, Aigner A, et al. (1997). "A secreted FGF-binding protein can serve as the angiogenic switch in human cancer". Nat. Med. 3 (10): 1137–40. doi:10.1038/nm1097-1137. PMID 9334727.
Wang XC, Chen JH, Crab JW, Sato JD (1998). "Purification of heparin-binding protein HBp17 and identification of HBp17 heparin binding site". Biochem. Mol. Biol. Int. 46 (1): 81–7. doi:10.1080/15216549800203582. PMID 9784842.
Harris VK, Coticchia CM, Kagan BL, et al. (2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated through both MEK/ERK and p38 signal transduction pathways". J. Biol. Chem. 275 (15): 10802–11. doi:10.1074/jbc.275.15.10802. PMID 10753873.
Sauter ER, Nesbit M, Tichansky D, et al. (2001). "Fibroblast growth factor-binding protein expression changes with disease progression in clinical and experimental human squamous epithelium". Int. J. Cancer. 92 (3): 374–81. doi:10.1002/ijc.1207. PMID 11291074.
Chen JH, Wang XC, Sato JD (2001). "Bifunctional effects of heparin-binding protein HBp17 on DNA synthesis in cells". Cell Biol. Int. 25 (6): 567–70. doi:10.1006/cbir.2000.0688. PMID 11407864.
Tassi E, Al-Attar A, Aigner A, et al. (2001). "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein". J. Biol. Chem. 276 (43): 40247–53. doi:10.1074/jbc.M104933200. PMID 11509569.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beer HD, Bittner M, Niklaus G, et al. (2005). "The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair". Oncogene. 24 (34): 5269–77. doi:10.1038/sj.onc.1208560. PMID 15806171.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Xie B, Tassi E, Swift MR, et al. (2006). "Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display". J. Biol. Chem. 281 (2): 1137–44. doi:10.1074/jbc.M510754200. PMID 16257968.
Ray PE, Tassi E, Liu XH, Wellstein A (2006). "Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome". Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 (1): R105–13. doi:10.1152/ajpregu.00492.2005. PMID 16352855.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137440 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048373 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11148217-5] Mongiat M, Otto J, Oldershaw R, Ferrer F, Sato JD, Iozzo RV (Mar 2001). "Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263–71. doi:10.1074/jbc.M011493200. PMID 11148217.

[pmid1885605-6] Wu DQ, Kan MK, Sato GH, Okamoto T, Sato JD (Oct 1991). "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25): 16778–85. PMID 1885605.

[entrez-7] "Entrez Gene: FGFBP1 fibroblast growth factor binding protein 1".

FGFBP1

Interactions

References

Further reading