FEM1A

Fem-1 homolog A is a protein that in humans is encoded by the FEM1A gene. [5]

FEM1A
Identifiers
Aliases	FEM1A, EPRAP, fem-1 homolog A
External IDs	OMIM: 613538 MGI: 1335089 HomoloGene: 7713 GeneCards: FEM1A
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,791,734 bp[1] End 4,801,273 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 D|17 29.24 cM Start 56,256,810 bp[2] End 56,263,610 bp[2]
Gene ontology Molecular function • EP4 subtype prostaglandin E2 receptor binding • ubiquitin-protein transferase activity Cellular component • cytoplasm • cytosol Biological process • negative regulation of inflammatory response • protein ubiquitination • regulation of ubiquitin-protein transferase activity • post-translational modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55527	14154
Ensembl	ENSG00000141965	ENSMUSG00000043683
UniProt	Q9BSK4	Q9Z2G1
RefSeq (mRNA)	NM_018708	NM_010192
RefSeq (protein)	NP_061178	NP_034322
Location (UCSC)	Chr 19: 4.79 – 4.8 Mb	Chr 17: 56.26 – 56.26 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000141965 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043683 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Fem-1 homolog A". Retrieved 2018-09-21.

Further reading

• Ventura-Holman T, Hahn H, Subauste JS, Maher JF (2005). "The Fem1a gene is downregulated in Rhabdomyosarcoma". Tumour Biol. 26 (6): 294–9. doi:10.1159/000089261. PMID 16254458.
• Maher JF, Hines RS, Futterweit W, Crawford S, Lu D, Shen P, Oefner P, Kazi M, Wilson JG, Subauste JS, Cowan BD (December 2005). "FEM1A is a candidate gene for polycystic ovary syndrome". Gynecol. Endocrinol. 21 (6): 330–5. doi:10.1080/09513590500431458. PMID 16390781.
• Minami M, Shimizu K, Okamoto Y, Folco E, Ilasaca ML, Feinberg MW, Aikawa M, Libby P (April 2008). "Prostaglandin E receptor type 4-associated protein interacts directly with NF-kappaB1 and attenuates macrophage activation". J. Biol. Chem. 283 (15): 9692–703. doi:10.1074/jbc.M709663200. PMC 2442287. PMID 18270204.
• Goodarzi MO, Maher JF, Cui J, Guo X, Taylor KD, Azziz R (December 2008). "FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome". Hum. Reprod. 23 (12): 2842–9. doi:10.1093/humrep/den324. PMC 2583941. PMID 18757445.
• Goodarzi MO, Maher JF, Cui J, Guo X, Taylor KD, Azziz R (December 2008). "FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome". Hum. Reprod. 23 (12): 2842–9. doi:10.1093/humrep/den324. PMC 2583941. PMID 18757445.
• Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
• McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (December 2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC 2810344. PMID 19948975.
• Ewens KG, Stewart DR, Ankener W, Urbanek M, McAllister JM, Chen C, Baig KM, Parker SC, Margulies EH, Legro RS, Dunaif A, Strauss JF, Spielman RS (May 2010). "Family-based analysis of candidate genes for polycystic ovary syndrome". J. Clin. Endocrinol. Metab. 95 (5): 2306–15. doi:10.1210/jc.2009-2703. PMC 2869537. PMID 20200332.
• Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.