FDX2

Ferredoxin 2 is a protein that in humans is encoded by the FDX2 gene. It participates in heme A synthesis and iron-sulphur protein synthesis.[5]

FDX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Y5C
Identifiers
Aliases	FDX2, ferredoxin 1 like, FDX1L, ferredoxin 2, MEOAL
External IDs	OMIM: 614585 MGI: 1915415 HomoloGene: 31955 GeneCards: FDX2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 10,310,045 bp[1] End 10,316,015 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A3 Start 21,067,520 bp[2] End 21,073,614 bp[2]
Gene ontology Molecular function • iron-sulfur cluster binding • GO:0001948 protein binding • metal ion binding • 2 iron, 2 sulfur cluster binding • electron transfer activity Cellular component • mitochondrial matrix • mitochondrion Biological process • C21-steroid hormone biosynthetic process • sterol metabolic process • oxidation-reduction process • small molecule metabolic process • electron transport chain Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	112812	68165
Ensembl	ENSG00000267673	ENSMUSG00000079677
UniProt	Q6P4F2	Q9CPW2
RefSeq (mRNA)	NM_080665 NM_001031734	NM_001039824
RefSeq (protein)	NP_001026904	NP_001034913
Location (UCSC)	Chr 19: 10.31 – 10.32 Mb	Chr 9: 21.07 – 21.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mutations in FDX2 cause mitochondrial myopathy.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000267673 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000079677 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Ferredoxin 2".
6. Spiegel R, Saada A, Halvardson J, Soiferman D, Shaag A, Edvardson S, Horovitz Y, Khayat M, Shalev SA, Feuk L, Elpeleg O (July 2014). "Deleterious mutation in FDX1L gene is associated with a novel mitochondrial muscle myopathy". European Journal of Human Genetics. 22 (7): 902–6. doi:10.1038/ejhg.2013.269. PMC 4060119. PMID 24281368.

Further reading

• Sheftel AD, Stehling O, Pierik AJ, Elsässer HP, Mühlenhoff U, Webert H, Hobler A, Hannemann F, Bernhardt R, Lill R (June 2010). "Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 107 (26): 11775–80. doi:10.1073/pnas.1004250107. PMC 2900682. PMID 20547883.