FCRLA

Fc receptor-like A is a protein that in humans is encoded by the FCRLA gene.[5][6]

FCRLA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HWN
Identifiers
Aliases	FCRLA, FCRL, FCRL1, FCRLM1, FCRLX, FCRLb, FCRLc1, FCRLc2, FCRLd, FCRLe, FCRX, FREB, Fc receptor like A
External IDs	OMIM: 606891 MGI: 2138647 HomoloGene: 13106 GeneCards: FCRLA
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 161,706,972 bp[1] End 161,714,352 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,917,576 bp[2] End 170,927,583 bp[2]
Orthologs
Species	Human	Mouse
Entrez	84824	98752
Ensembl	ENSG00000132185	ENSMUSG00000038421
UniProt	Q7L513	Q920A9
RefSeq (mRNA)	NM_001184866 NM_001184867 NM_001184870 NM_001184871 NM_001184872 NM_001184873 NM_032738 NM_001366195 NM_001366196	NM_001160215 NM_145141
RefSeq (protein)	NP_001171795 NP_001171796 NP_001171799 NP_001171800 NP_001171801 NP_001171802 NP_116127 NP_001353124 NP_001353125	NP_001153687 NP_660123
Location (UCSC)	Chr 1: 161.71 – 161.71 Mb	Chr 1: 170.92 – 170.93 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Receptors for the Fc fragment of IgG, or FCGRs (see MIM 146790), are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. All FCGR genes map to human chromosome 1. Additional genes in this region, including FREB, encode FCGR homologs that are selectively expressed in B cells and may be implicated in B-cell development and lymphomagenesis.[supplied by OMIM][6]

References

1. GRCh38: Ensembl release 89: ENSG00000132185 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038421 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mechetina LV, Najakshin AM, Volkova OY, Guselnikov SV, Faizulin RZ, Alabyev BY, Chikaev NA, Vinogradova MS, Taranin AV (Dec 2001). "FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features". Eur J Immunol. 32 (1): 87–96. doi:10.1002/1521-4141(200201)32:1<87::AID-IMMU87>3.0.CO;2-#. PMID 11754007.
6. "Entrez Gene: FCRLA Fc receptor-like A".

Further reading

• Facchetti F, Cella M, Festa S, et al. (2002). "An unusual Fc receptor-related protein expressed in human centroblasts". Proc. Natl. Acad. Sci. U.S.A. 99 (6): 3776–81. doi:10.1073/pnas.022042699. PMC 122600. PMID 11891275.
• Davis RS, Li H, Chen CC, et al. (2003). "Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells". Int. Immunol. 14 (9): 1075–83. doi:10.1093/intimm/dxf074. PMID 12202404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huizinga TW, Ioan-Facsinay A (2004). "Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways". J. Rheumatol. 30 (9): 1904–6. PMID 12966588.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Inozume T, Matsuzaki Y, Kurihara S, et al. (2005). "Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients". Int. J. Cancer. 114 (2): 283–90. doi:10.1002/ijc.20735. PMID 15551350.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.