FCHO1

FCH domain only 1 is a protein that in humans is encoded by the FCHO1 gene. [5]

FCHO1
Identifiers
Aliases	FCHO1, FCH domain only 1, FCH and mu domain containing endocytic adaptor 1
External IDs	OMIM: 613437 MGI: 1921265 HomoloGene: 22869 GeneCards: FCHO1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 17,747,718 bp[1] End 17,788,568 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 71,708,387 bp[2] End 71,725,716 bp[2]
Gene ontology Molecular function • AP-2 adaptor complex binding • GO:0001948 protein binding • phospholipid binding • microtubule binding • cytoskeletal protein binding • tubulin binding Cellular component • cell membrane • clathrin-coated pit • membrane • clathrin-coated vesicle • nucleoplasm • cytosol • cytoplasm • cytoskeleton • AP-2 adaptor complex Biological process • clathrin-dependent endocytosis • endocytosis • clathrin coat assembly • membrane organization • plasma membrane tubulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23149	74015
Ensembl	ENSG00000130475	ENSMUSG00000070000
UniProt	O14526	Q8K285
RefSeq (mRNA)	NM_001161357 NM_001161358 NM_001161359 NM_015122	NM_028715
RefSeq (protein)	NP_001154829 NP_001154830 NP_001154831 NP_055937	NP_082991
Location (UCSC)	Chr 19: 17.75 – 17.79 Mb	Chr 8: 71.71 – 71.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000130475 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070000 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FCH domain only 1". Retrieved 2017-05-13.

Further reading

• Sakaushi S, Inoue K, Zushi H, Senda-Murata K, Fukada T, Oka S, Sugimoto K (2007). "Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation". Biosci. Biotechnol. Biochem. 71 (7): 1764–8. doi:10.1271/bbb.60720. PMID 17617719.
• Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010). "FCHo proteins are nucleators of clathrin-mediated endocytosis". Science. 328 (5983): 1281–4. doi:10.1126/science.1188462. PMC 2883440. PMID 20448150.
• Umasankar PK, Sanker S, Thieman JR, Chakraborty S, Wendland B, Tsang M, Traub LM (2012). "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning". Nat. Cell Biol. 14 (5): 488–501. doi:10.1038/ncb2473. PMC 3354769. PMID 22484487.