FCER1A

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, also known as FCER1A, is a protein which in humans is encoded by the FCER1A gene.[5]

FCER1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCER1A, FCE1A, FcERI, Fc fragment of IgE receptor Ia
External IDsOMIM: 147140 MGI: 95494 HomoloGene: 1516 GeneCards: FCER1A
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.2Start159,289,714 bp[1]
End159,308,224 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2205

14125

Ensembl

ENSG00000179639

ENSMUSG00000005339

UniProt

P12319

P20489

RefSeq (mRNA)

NM_002001

NM_010184

RefSeq (protein)

NP_001992

NP_034314

Location (UCSC)Chr 1: 159.29 – 159.31 MbChr 1: 173.22 – 173.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The high affinity IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes—potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha (this protein), beta, and gamma; only the alpha subunit is glycosylated.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000179639 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005339 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pang J, Taylor GR, Munroe DG, Ishaque A, Fung-Leung WP, Lau CY, Liu FT, Zhou L (December 1993). "Characterization of the gene for the human high affinity IgE receptor (Fc epsilon RI) alpha-chain". J. Immunol. 151 (11): 6166–74. PMID 8245459.
  6. "Entrez Gene: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide".

Further reading

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