FBXO6

F-box only protein 6 is a protein that in humans is encoded by the FBXO6 gene.[5][6][7]

FBXO6
Identifiers
Aliases	FBXO6, FBG2, FBS2, FBX6, Fbx6b, F-box protein 6
External IDs	OMIM: 605647 MGI: 1354743 HomoloGene: 9274 GeneCards: FBXO6
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.22 Start 11,664,200 bp[1] End 11,674,354 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 E2|4 78.67 cM Start 148,145,716 bp[2] End 148,152,140 bp[2]
Gene ontology Molecular function • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • carbohydrate binding • ubiquitin-protein transferase activity • GO:0001948 protein binding Cellular component • cytoplasm • SCF ubiquitin ligase complex • endoplasmic reticulum quality control compartment • cytosol Biological process • cellular response to DNA damage stimulus • DNA damage checkpoint • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • response to unfolded protein • DNA repair • protein ubiquitination • proteolysis • ubiquitin-dependent ERAD pathway • glycoprotein catabolic process • protein polyubiquitination • post-translational modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26270	50762
Ensembl	ENSG00000116663	ENSMUSG00000055401
UniProt	Q9NRD1	Q9QZN4
RefSeq (mRNA)	NM_018438	NM_001163704 NM_001163705 NM_001163706 NM_001163707 NM_015797
RefSeq (protein)	NP_060908	NP_001157176 NP_001157177 NP_001157178 NP_001157179 NP_056612
Location (UCSC)	Chr 1: 11.66 – 11.67 Mb	Chr 4: 148.15 – 148.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000116663 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000055401 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
6. Ilyin GP, Rialland M, Pigeon C, Guguen-Guillouzo C (Nov 2000). "cDNA cloning and expression analysis of new members of the mammalian F-box protein family". Genomics. 67 (1): 40–7. doi:10.1006/geno.2000.6211. PMID 10945468.
7. "Entrez Gene: FBXO6 F-box protein 6".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yoshida Y, Tokunaga F, Chiba T, et al. (2003). "Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains". J. Biol. Chem. 278 (44): 43877–84. doi:10.1074/jbc.M304157200. PMID 12939278.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
• Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.