FARP1

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.[5][6]

FARP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H6Y
Identifiers
Aliases	FARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDs	OMIM: 602654 MGI: 2446173 HomoloGene: 38098 GeneCards: FARP1
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.2 Start 98,142,562 bp[1] End 98,455,176 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E5 Start 121,035,200 bp[2] End 121,283,744 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity • cytoskeletal protein binding • Rho guanyl-nucleotide exchange factor activity Cellular component • cytosol • cell projection • membrane • filopodium • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • dendritic spine • synapse • cell junction • dendrite • neuron projection • cytoskeleton • cytoplasm Biological process • dendrite morphogenesis • negative regulation of phosphatase activity • multicellular organism development • synapse assembly • regulation of Rho protein signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10160	223254
Ensembl	ENSG00000152767	ENSMUSG00000025555
UniProt	Q9Y4F1	F8VPU2
RefSeq (mRNA)	NM_001001715 NM_001286839 NM_005766	NM_134082
RefSeq (protein)	NP_001001715 NP_001273768 NP_005757	NP_598843
Location (UCSC)	Chr 13: 98.14 – 98.46 Mb	Chr 14: 121.04 – 121.28 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000152767 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025555 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K, Kato Y (Jan 1998). "Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors". Biochem Biophys Res Commun. 241 (2): 369–75. doi:10.1006/bbrc.1997.7826. PMID 9425278.
6. "Entrez Gene: FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)".

Further reading

• Zhuang B, Su YS, Sockanathan S (February 2009). "FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling". Neuron. 61 (3): 359–72. doi:10.1016/j.neuron.2008.12.022. PMC 2654783. PMID 19217374.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• FARP1 human gene location in the UCSC Genome Browser.
• FARP1 human gene details in the UCSC Genome Browser.