Extended synaptotagmin-2

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene.[5][6]

ESYT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMG, 4NPJ, 4NPK, 4P42
Identifiers
Aliases	ESYT2, CHR2SYT, E-Syt2, FAM62B, extended synaptotagmin protein 2, extended synaptotagmin 2
External IDs	OMIM: 616691 MGI: 1261845 HomoloGene: 32699 GeneCards: ESYT2
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.3 Start 158,730,995 bp[1] End 158,830,253 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F2|12 62.65 cM Start 116,281,196 bp[2] End 116,391,050 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium-dependent phospholipid binding • calcium ion binding • GO:0001948 protein binding • metal ion binding • phosphatidylinositol binding • phosphatidylethanolamine binding • phosphatidylcholine binding • identical protein binding • lipid binding • cadherin binding Cellular component • intrinsic component of endoplasmic reticulum membrane • organelle membrane contact site • integral component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • integral component of plasma membrane • membrane • endoplasmic reticulum • endoplasmic reticulum membrane • endoplasmic reticulum-plasma membrane contact site Biological process • lipid transport • endocytosis • glycosphingolipid metabolic process • transport • endoplasmic reticulum-plasma membrane tethering Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57488	52635
Ensembl	ENSG00000117868	ENSMUSG00000021171
UniProt	A0FGR8	Q3TZZ7
RefSeq (mRNA)	NM_020728	NM_028731
RefSeq (protein)	NP_065779 NP_001354702	NP_083007
Location (UCSC)	Chr 7: 158.73 – 158.83 Mb	Chr 12: 116.28 – 116.39 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000117868 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021171 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
6. "Entrez Gene: FAM62B family with sequence similarity 62 (C2 domain containing) member B".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
• Craxton M (2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.