FAF1

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene.[5][6]

FAF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFAF1, HFAF1s, UBXD12, UBXN3A, hCGI-03, Fas associated factor 1
External IDsOMIM: 604460 MGI: 109419 HomoloGene: 5120 GeneCards: FAF1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p32.3Start50,437,028 bp[1]
End50,960,267 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11124

14084

Ensembl

ENSG00000185104

ENSMUSG00000010517

UniProt

Q9UNN5

P54731

RefSeq (mRNA)

NM_131917
NM_007051

NM_007983

RefSeq (protein)

NP_008982

NP_032009

Location (UCSC)Chr 1: 50.44 – 50.96 MbChr 4: 109.68 – 109.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000185104 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000010517 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ryu SW, Chae SK, Lee KJ, Kim E (Oct 1999). "Identification and characterization of human Fas associated factor 1, hFAF1". Biochem Biophys Res Commun. 262 (2): 388–94. doi:10.1006/bbrc.1999.1217. PMID 10462485.
  6. "Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1".

Further reading


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