F-box protein 16

F-box protein 16 is a protein that in humans is encoded by the FBXO16 gene.[5]

FBXO16
Identifiers
AliasesFBXO16, FBX16, F-box protein 16
External IDsOMIM: 608519 MGI: 1354706 HomoloGene: 9273 GeneCards: FBXO16
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p21.1Start28,348,287 bp[1]
End28,490,278 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

157574

50759

Ensembl

ENSG00000214050

ENSMUSG00000034532

UniProt

Q8IX29

Q9QZM9

RefSeq (mRNA)

NM_172366
NM_001258211

NM_015795
NM_001360381
NM_001360383

RefSeq (protein)

NP_001245140
NP_758954

NP_056610
NP_001347310
NP_001347312

Location (UCSC)Chr 8: 28.35 – 28.49 MbChr 14: 65.27 – 65.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene.

gollark: ++supported_langs objective
gollark: Neither does TIO apparently.
gollark: ++exec -L c-gcc```c#include <stdio.h>int main(int apiohazard, char* *apioform) { printf("out: %s", (char*)apioform); return 0;}```
gollark: funcŧionnnnnnnnnnnnnnnn
gollark: ++exec -L c-gcc```c#include <stdio.h>int main(int apiohazard, char* *apioform) { printf("out: %s", (char*)main); return 0;}```

References
  1. GRCh38: Ensembl release 89: ENSG00000214050 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034532 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: F-box protein 16". Retrieved 2016-09-13.

Further reading
  • Cheng H, Ma Y, Ni X, Jiang M, Guo L, Jin W, Xu W, Cao G, Ji C, Yin K, Gu S, Ma Y, Xie Y, Mao Y (2002). "cDNA cloning and expression analysis of a novel human F-box only protein". Mol. Cells. 14 (1): 56–9. PMID 12243353.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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