Exosome component 5

Exosome component 5, also known as EXOSC5, is a human gene, which is part of the exosome complex.[5]

EXOSC5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC5, RRP41B, RRP46, Rrp46p, hRrp46p, p12B, Exosome component 5
External IDs	OMIM: 606492 MGI: 107889 HomoloGene: 5981 GeneCards: EXOSC5
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 41,386,374 bp[1] End 41,397,359 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 13.96 cM Start 25,659,164 bp[2] End 25,671,368 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • 3'-5'-exoribonuclease activity • exoribonuclease activity • GO:0001948 protein binding • RNA binding Cellular component • cytoplasm • cytosol • exosome (RNase complex) • nuclear exosome (RNase complex) • cytoplasmic exosome (RNase complex) • nucleolus • transcriptionally active chromatin • cell nucleus • nucleoplasm Biological process • regulation of mRNA stability • nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' • rRNA 3'-end processing • rRNA catabolic process • DNA deamination • nuclear mRNA surveillance • defense response to virus • exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay • U4 snRNA 3'-end processing • polyadenylation-dependent snoRNA 3'-end processing • RNA catabolic process • rRNA processing • RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56915	27998
Ensembl	ENSG00000077348	ENSMUSG00000061286
UniProt	Q9NQT4	Q9CRA8
RefSeq (mRNA)	NM_020158	NM_138586
RefSeq (protein)	NP_064543	NP_613052
Location (UCSC)	Chr 19: 41.39 – 41.4 Mb	Chr 7: 25.66 – 25.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Exosome component 5 has been shown to interact with:

• Exosome component 1,[6][7] and
• Exosome component 8.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000077348 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061286 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EXOSC5 exosome component 5".
6. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/s0022-2836(02)00947-6. PMID 12419256.
7. Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (Jan 2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
• Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. PMID 11110791.
• Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
• Raijmakers R, Noordman YE, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions of hCsl4p with other human exosome subunits". J. Mol. Biol. 315 (4): 809–18. doi:10.1006/jmbi.2001.5265. PMID 11812149.
• Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
• Yang XF, Wu CJ, Chen L, et al. (2002). "CML28 is a broadly immunogenic antigen, which is overexpressed in tumor cells". Cancer Res. 62 (19): 5517–22. PMID 12359762.
• Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J. Mol. Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Zhou H, Zhang D, Wang Y, et al. (2006). "Induction of CML28-specific cytotoxic T cell responses using co-transfected dendritic cells with CML28 DNA vaccine and SOCS1 small interfering RNA expression vector". Biochem. Biophys. Res. Commun. 347 (1): 200–7. doi:10.1016/j.bbrc.2006.06.093. PMID 16815301.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.