Exosite

An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein.[1]

For the software company, see Exosite (company).

This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically must be occupied.[2] Exosites have recently become a topic of increased interest in biomedical research as potential drug targets.[3][4]

References
  1. IngentaConnect Manipulation of thrombin exosite I, by ligand-directed covalent m
  2. Congress of the International Society on Thrombosis and Haemostasis Archived November 26, 2004, at the Wayback Machine
  3. Muller, Jens (2009). "An Exosite-Specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and Enhances Inhibition by Protein C Inhibitor". Chemistry & Biology. Cell.com. 16 (4): 442–51. doi:10.1016/j.chembiol.2009.03.007. PMID 19389630. Retrieved 11 May 2013.
  4. Serine Endopeptidases: Advances in Research and Application: 2011 Edition. ScholarlyAdditions. 2012-01-09. ISBN 9781464926587. Retrieved 11 May 2013.


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