Eryptosis

Eryptosis (Erythrocyte apoptosis or Red blood cell programmed death) is a type of apoptosis that occurs in injured erythrocytes (RBCs) due to various factors including hyperosmolarity, oxidative stress, energy depletion, heavy metals exposure or xenobiotics. Like apoptosis, eryptosis is characterized by cell shrinkage, membrane blebbing, activation of proteases, and phosphatidylserine exposure at the outer membrane leaflet.[1][2]

Causes

Conditions with excessive eryptosis include[3]:

  • Iron deficiency anemia
  • Lead or mercury intoxication
  • Sickle cell anemia
  • Thalassemia
  • G6PD deficiency
  • Malaria
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References
  1. Repsold, Lisa; Joubert, Anna Margaretha (2018). "Eryptosis: An Erythrocyte's Suicidal Type of Cell Death". BioMed Research International. 2018: 1–10. doi:10.1155/2018/9405617. ISSN 2314-6133. PMC 5817309. PMID 29516014.
  2. Pretorius, Etheresia; du Plooy, Jeanette N.; Bester, Janette (2016). "A Comprehensive Review on Eryptosis". Cellular Physiology and Biochemistry. 39 (5): 1977–2000. doi:10.1159/000447895. ISSN 1015-8987. PMID 27771701.
  3. Lang, Florian; Lang, Karl S.; Lang, Philipp A.; Huber, Stephan M.; Wieder, Thomas (July 2006). "Mechanisms and Significance of Eryptosis". Antioxidants & Redox Signaling. 8 (7–8): 1183–1192. doi:10.1089/ars.2006.8.1183. ISSN 1523-0864. PMID 16910766.
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