Erin M. Schuman

Erin Schuman, born May 15, 1963 in California, USA, is a neurobiologist who studies neuronal synapses. She is currently a Director at the Max Planck Institute for Brain Research.[1]

Career

Erin Schuman attended the University of Southern California (USC), where she received her B.A. in Psychology (1985). She continued her education to obtain a Ph.D. in Neuroscience from Princeton University (1990). She conducted postdoctoral research from 1990-1993 in Daniel V. Madison’s lab in the Molecular and Cellular Physiology Department at Stanford University. From there, Schuman was recruited to join the faculty in the Division of Biology at the California Institute of Technology where she moved up the ranks from Assistant to Full Professor. During this time, she was also appointed investigator at the Howard Hughes Medical Institute. In 2009, she was recruited as the Director of Max Planck Institute for Brain Research in Frankfurt am Main, Germany, at which she holds her current position.[2]

Research

The Schuman lab studies the properties of mRNAs and proteins (e.g. the transcriptomes and proteomes) distributed throughout the neuron.[3] Her research has examined how stability in neuronal processes can be brought about by local cell biological processes, like protein synthesis, allowing synapses to respond rapidly and appropriately to changing stimuli. The Schuman lab demonstrated the first functional role for local translation in neurons. In 1996, in the course of exploring how neurotrophins enhance synaptic transmission, Schuman together with graduate student Hyejin Kang made the discovery that local protein synthesis within dendrites is required for this form of synaptic plasticity.[4] She obtained direct proof that protein synthesis occurs in intact, but isolated dendrites.[5] This, together with a few other key observations, gave birth to the field of local translation. Her team discovered, using next generation sequencing, over 2500 mRNAs localized to the neuropil.[6] In addition, Schuman and collaborators (Dave Tirrell, Caltech[7] and Daniela Dieterich, Magdeburg[8]) has made invaluable technical contributions most notable perhaps is the development of non-canonical amino acid metabolic labelling, click chemistry, and mutation of cell-biological enzymes (the BONCAT and FUNCAT techniques) enabling the labelling, purification, identification and visualization of newly synthesized proteins in neurons and other cells.[9][10][11][12]

Advocacy for Women in Neuroscience

In addition to her research and professorship, Erin Schuman has been committed to promoting the professional advancement of women in the field of neuroscience. Schuman made it a condition of her recruitment to Max Planck that a new child care facility be built on campus. She also spearheaded an initiative outlining changes in recruitment practices aimed at doubling the percentage of female directors in the Max Planck Society's Biology & Medicine Section to 20% by 2020. In 2018, she received the Society for Neuroscience Mika Salpeter Lifetime Achievement Award in for her teaching, mentoring, and advocacy.[13]

Awards and Recognition

Selected awards:[14]

  • Louis-Jeantet Price for Medicine (2020)
  • Society for Neuroscience, Salpeter Lifetime Achievement Award (2018)
  • Elected Member Academia Europaea (2017)
  • Elected Member German National Academy of Sciences Leopoldina (2017)
  • European Research Council, Advanced Investigator Grant (2017)
  • Forbes Lectures, Marine Biological Laboratory (2016)
  • Elected EMBO member (2014)
  • Alexander Cruickshank Lecture, Gordon Research Conference (2013)
  • Hodgkin-Huxley-Katz Prize (2013)
  • Norbert Elsner Lecture, German Neuroscience Society (2013)
  • European Research Council, Advanced Investigator Grant (2011)
  • Gerard Lecture, University of California, Irvine (2008)
  • Howard Hughes Medical Institute Investigator (2005)
  • Howard Hughes Medical Institute Associate Investigator (2002)
  • Howard Hughes Medical Institute Assistant Investigator (1997)
  • Ferguson Biology Undergraduate Teaching Prize (1996)
  • Beckman Young Investigator Award (1996-1998)
  • Ferguson Biology Graduate Teaching Prize (1995)
  • American Association of University Women Emerging Scholar (1995)
  • Pew Biomedical Scholar (1995-1999)
  • John Merck Scholar (1994-1998)
  • Alfred P. Sloan Research Fellow (1994-1996)
  • McKnight Scholars Award (declined) (1994-1996)
  • Katherine McCormick Foundation fellow (1991)
  • NIH postdoctoral fellowship (1990)
  • NIH predoctoral fellow (1986)
  • Phi Beta Kappa, graduation with honors (1985)
  • Sigma Xi Outstanding Undergraduate Research Award (1985)
gollark: I can probably do >4 aeons, though not very neatly.
gollark: *since technically they both have wants...*
gollark: *actually, yes, should be okay*
gollark: *probably not*
gollark: *ask for an IOU for 5 million truffles*

References
  1. http://brain.mpg.de/fileadmin/user_upload/Documents/Schuman_full_CV_October_2018.pdf
  2. https://brain.mpg.de/fileadmin/user_upload/Documents/Schuman_full_CV_April_2019.pdf}
  3. "Schuman Department". brain.mpg.de.
  4. Kang, Hyejin; Schuman, Erin M. (6 September 1996). "A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity". Science. 273 (5280): 1402–1406. doi:10.1126/science.273.5280.1402. ISSN 0036-8075. PMID 8703078.
  5. Aakalu, Girish; Smith, W. Bryan; Nguyen, Nhien; Jiang, Changan; Schuman, Erin M. (1 May 2001). "Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons". Neuron. 30 (2): 489–502. doi:10.1016/S0896-6273(01)00295-1. ISSN 0896-6273. PMID 11395009.
  6. Cajigas, Iván J.; Tushev, Georgi; Will, Tristan J.; tom Dieck, Susanne; Fuerst, Nicole; Schuman, Erin M. (May 2012). "The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging". Neuron. 74 (3): 453–466. doi:10.1016/j.neuron.2012.02.036. PMC 3627340. PMID 22578497.
  7. "Reinterpreting the Genetic Code: Non-Canonical Amino Acids in Protein Design, Evolution and Analysis - Caltech Tirrell Lab". tirrell-lab.caltech.edu.
  8. "Daniela Dieterich - MSc Integrative Neuroscience Magdeburg". www.neuroscience-magdeburg.de.
  9. Dieterich, D. C.; Link, A. J.; Graumann, J.; Tirrell, D. A.; Schuman, E. M. (12 June 2006). "Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)". Proceedings of the National Academy of Sciences. 103 (25): 9482–9487. doi:10.1073/pnas.0601637103. ISSN 0027-8424. PMC 1480433.
  10. Ngo, John T; Champion, Julie A; Mahdavi, Alborz; Tanrikulu, I Caglar; Beatty, Kimberly E; Connor, Rebecca E; Yoo, Tae Hyeon; Dieterich, Daniela C; Schuman, Erin M; Tirrell, David A (9 August 2009). "Cell-selective metabolic labeling of proteins". Nature Chemical Biology. 5 (10): 715–717. doi:10.1038/nchembio.200. PMC 3176724. PMID 19668194.
  11. Dieterich, Daniela C; Hodas, Jennifer J L; Gouzer, Géraldine; Shadrin, Ilya Y; Ngo, John T; Triller, Antoine; Tirrell, David A; Schuman, Erin M (13 June 2010). "In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons". Nature Neuroscience. 13 (7): 897–905. doi:10.1038/nn.2580. PMC 2920597.
  12. tom Dieck, Susanne; Kochen, Lisa; Hanus, Cyril; Heumüller, Maximilian; Bartnik, Ina; Nassim-Assir, Belquis; Merk, Katrin; Mosler, Thorsten; Garg, Sakshi; Bunse, Stefanie; Tirrell, David A; Schuman, Erin M (16 March 2015). "Direct visualization of newly synthesized target proteins in situ". Nature Methods. 12 (5): 411–414. doi:10.1038/nmeth.3319. PMC 4414919.
  13. "Erin Schuman has been awarded the Mika Salpeter Lifetime Achievement Award". brain.mpg.de.
  14. "CV Schuman".
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