Elongator complex protein 5

Elongator complex protein 5 (ELP5) also known as dermal papilla-derived protein 6 (DERP6) is a protein that in humans is encoded by the ELP5 gene.[5][6]

ELP5
Identifiers
Aliases	ELP5, C17orf81, DERP6, MST071, MSTP071, HSPC002, elongator acetyltransferase complex subunit 5
External IDs	OMIM: 615019 MGI: 1859017 HomoloGene: 10291 GeneCards: ELP5
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,251,416 bp[1] End 7,259,940 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 69,968,222 bp[2] End 69,982,517 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cell nucleus • cytoplasm • Elongator holoenzyme complex • cytosol Biological process • regulation of transcription, DNA-templated • positive regulation of cell migration • transcription, DNA-templated • tRNA wobble uridine modification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23587	54351
Ensembl	ENSG00000170291 ENSG00000288485	ENSMUSG00000018565
UniProt	Q8TE02	Q99L85
RefSeq (mRNA)	NM_015362 NM_203413 NM_203414 NM_203415	NM_001253700 NM_018740
RefSeq (protein)	NP_056177 NP_981958 NP_981959 NP_981960	NP_001240629 NP_061210
Location (UCSC)	Chr 17: 7.25 – 7.26 Mb	Chr 11: 69.97 – 69.98 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000288485 GRCh38: Ensembl release 89: ENSG00000170291, ENSG00000288485 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018565 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. "Entrez Gene: C17orf81 chromosome 17 open reading frame 81".

Further reading

• Yuan J, Tang W, Luo K, et al. (2006). "Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53". Mol. Biol. Rep. 33 (3): 151–8. doi:10.1007/s11033-006-6273-5. PMID 16850183.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.