Edward Slater

Edward Charles Slater FRS FAA (16 January 1917–26 March 2016), also known as Bill Slater, was an Australian biochemist who spent most of his career at the University of Amsterdam.

Edward Slater FRS FAA
Born	(1917-01-16)16 January 1917[1] Melbourne, Australia[2]
Died	26 March 2016(2016-03-26) (aged 99)[1] Painswick, UK
Alma mater	University of Melbourne BSc, MSc University of Cambridge PhD, ScD
Awards	FRS (1975) Order of the Netherlands Lion (1984)
Scientific career
Fields	bioenergetics
Institutions	University of Amsterdam
Doctoral advisor	David Keilin
Notable students	Piet Borst

Early life and education

Slater was raised in Australia. He received a training in biochemistry at the Ormond College of the University of Melbourne.[1][2][3] In 1946, he moved to Cambridge, where he earned his PhD under the supervision of David Keilin.[2][3]

Career

In 1955, Slater joined the medical faculty of the University of Amsterdam, where he remained until retiring in 1985.[1][2][3] He is recognised for his contributions to the development of Dutch biochemistry.[3][4]

Slater managed the journal Biochimica et Biophysica Acta, turning it into one of the most influential publications in the field.[3][4] He wrote a history of the journal, Biochimica et biophysica acta: the story of a biochemical journal, which was published in 1986.[1]

He served as the president of the International Union of Biochemistry and Molecular Biology from 1988 until 1991.[5]

Research

Slater made contributions to the identification and understanding of the physiological role of the components of the respiratory chain, especially of the various cytochrome b complexes, iron–sulfur proteins and other iron-containing substances. He showed that the binding of certain inhibitors of oxidative phosphorylation acting at different sites (antimycin on electron transport, oligomycin on the coupling between electron transport and oxidative phosphorylation, and aurovertin in the ATP-synthesising enzyme) can be positively cooperative, and that the degree of cooperativity depends on the state of the mitochondrial membrane. He also demonstrated negative cooperative binding of a ligand to an enzyme (nicotinamide adenine dinucleotide to glyceraldehyde phosphate dehydrogenase), which has implications for the mechanisms of cooperative binding generally.[6]

Awards and honours

In 1964, Slater became a member of the Royal Netherlands Academy of Arts and Sciences.[1] He was elected a Fellow of the Royal Society (FRS) in 1975.[6][7]

In 1984, he was appointed a Knight in the Order of the Netherlands Lion, and in 1985 he was elected a Corresponding Fellow of the Australian Academy of Science.[5]

He was awarded honorary degrees by the University of Southampton (1993) and the University of Bari (1998).[1]

References

1. "Slater, Edward Charles". Who's Who. ukwhoswho.com. 2017 (online ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription or UK public library membership required) (subscription required)
2. "Retrospective - E. C. Slater (1917 – 2016)". ASBMB (American Society for Biochemistry and Molecular Biology). 2016-09-01. Retrieved 2017-12-17.
3. Borst, Piet (2017-03-01). "Edward Charles Slater. 16 January 1917 — 26 March 2016". Biographical Memoirs of Fellows of the Royal Society. The Royal Society. 63: 527–551. doi:10.1098/rsbm.2016.0024. ISSN 0080-4606.
4. Amsterdam, Universiteit van. "In memoriam: E.C. Slater". GNGH (in Dutch). Archived from the original on 2016-06-13. Retrieved 2017-12-18.
5. "Slater, Edward Charles". Biographical entry. Encyclopedia of Australian Science. 1997-06-30. Retrieved 2017-12-18.
6. "Edward Slater". London: Royal Society. One or more of the preceding sentences may incorporate text from the royalsociety.org website where "all text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." "Royal Society Terms, conditions and policies". Archived from the original on 2017-07-10. Retrieved 2017-12-18.CS1 maint: BOT: original-url status unknown (link), "Intellectual property rights"
7. "EC/1975/24: Slater, Edward Charles". The Royal Society. Retrieved 17 December 2017.