EXTL3

Exostosin-like 3 is a protein that in humans is encoded by the EXTL3 gene.[5][6][7][8]

EXTL3
Identifiers
Aliases	EXTL3, BOTV, EXTL1L, EXTR1, REGR, RPR, exostosin like glycosyltransferase 3, ISDNA
External IDs	OMIM: 605744 MGI: 1860765 HomoloGene: 1103 GeneCards: EXTL3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.1 Start 28,600,469 bp[1] End 28,755,599 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 65,052,060 bp[2] End 65,149,855 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity • metal ion binding • transferase activity, transferring glycosyl groups Cellular component • integral component of membrane • membrane • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus Biological process • positive regulation of cell growth • IRE1-mediated unfolded protein response • heparan sulfate proteoglycan biosynthetic process • protein glycosylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2137	54616
Ensembl	ENSG00000012232	ENSMUSG00000021978
UniProt	O43909	Q9WVL6 Q6P1H4
RefSeq (mRNA)	NM_001440	NM_018788 NM_001360385
RefSeq (protein)	NP_001431	NP_061258 NP_001347314
Location (UCSC)	Chr 8: 28.6 – 28.76 Mb	Chr 14: 65.05 – 65.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000012232 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021978 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Hul W, Wuyts W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Bossuyt P, Willems PJ (Apr 1998). "Identification of a third EXT-like gene (EXTL3) belonging to the EXT gene family". Genomics. 47 (2): 230–7. doi:10.1006/geno.1997.5101. PMID 9479495.
6. Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ (Mar 1998). "Identification and characterization of a novel member of the EXT gene family, EXTL2". Eur J Hum Genet. 5 (6): 382–9. doi:10.1159/000484796. PMID 9450183.
7. Mizuno K, Irie S, Sato TA (Mar 2001). "Overexpression of EXTL3/EXTR1 enhances NF-kappaB activity induced by TNF-alpha". Cell Signal. 13 (2): 125–30. doi:10.1016/S0898-6568(00)00144-3. PMID 11257457.
8. "Entrez Gene: EXTL3 exostoses (multiple)-like 3".

Further reading

• Saito T, Seki N, Yamauchi M, et al. (1998). "Structure, chromosomal location, and expression profile of EXTR1 and EXTR2, new members of the multiple exostoses gene family". Biochem. Biophys. Res. Commun. 243 (1): 61–6. doi:10.1006/bbrc.1997.8062. PMID 9473480.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• McCormick C, Duncan G, Goutsos KT, Tufaro F (2000). "The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate". Proc. Natl. Acad. Sci. U.S.A. 97 (2): 668–73. doi:10.1073/pnas.97.2.668. PMC 15388. PMID 10639137.
• Kobayashi S, Akiyama T, Nata K, et al. (2000). "Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor". J. Biol. Chem. 275 (15): 10723–6. doi:10.1074/jbc.275.15.10723. PMID 10753861.
• Kim BT, Kitagawa H, Tamura Ji J, et al. (2002). "Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation". J. Biol. Chem. 277 (16): 13659–65. doi:10.1074/jbc.M111630200. PMID 11832488.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bishnupuri KS, Luo Q, Korzenik JR, et al. (2007). "Dysregulation of Reg gene expression occurs early in gastrointestinal tumorigenesis and regulates anti-apoptotic genes". Cancer Biol. Ther. 5 (12): 1714–20. doi:10.4161/cbt.5.12.3469. PMID 17106246.