ERGIC3

Endoplasmic reticulum-Golgi intermediate compartment protein 3 is a protein that in humans is encoded by the ERGIC3 gene.[5][6] It has been reported to be regulated by micro RNAs and may be important in a cancer.[7][8]

ERGIC3
Identifiers
Aliases	ERGIC3, C20orf47, CGI-54, Erv46, NY-BR-84, PRO0989, SDBCAG84, dJ477O4.2, ERGIC and golgi 3, C2orf47
External IDs	OMIM: 616971 MGI: 1913616 HomoloGene: 5289 GeneCards: ERGIC3
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22 Start 35,542,021 bp[1] End 35,557,634 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 77.32 cM Start 156,008,045 bp[2] End 156,018,279 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51614	66366
Ensembl	ENSG00000125991	ENSMUSG00000005881
UniProt	Q9Y282	Q9CQE7
RefSeq (mRNA)	NM_015966 NM_198398	NM_025516 NM_001356413 NM_001356414
RefSeq (protein)	NP_057050 NP_938408	NP_079792 NP_001343342 NP_001343343
Location (UCSC)	Chr 20: 35.54 – 35.56 Mb	Chr 2: 156.01 – 156.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000125991 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005881 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
6. "Entrez Gene: ERGIC3 ERGIC and golgi 3".
7. Zhang, Ling-yun; Liu, Min; Li, Xin; Tang, Hua (2013). "miR-490-3p Modulates Cell Growth and Epithelial to Mesenchymal Transition of Hepatocellular Carcinoma Cells by Targeting Endoplasmic Reticulum-Golgi Intermediate Compartment Protein 3 (ERGIC3)". Journal of Biological Chemistry. 288 (6): 4035–4047. doi:10.1074/jbc.M112.410506. ISSN 0021-9258. PMC 3567655. PMID 23212913.
8. Lin, Qing-Hai; Zhang, Kui-Dong; Duan, He-Xian; Liu, Min-Xia; Wei, Wan-Li; Cao, Yi (2015). "ERGIC3, which is regulated by miR-203a, is a potential biomarker for non-small cell lung cancer". Cancer Science. 106 (10): 1463–1473. doi:10.1111/cas.12741. ISSN 1347-9032. PMC 4638005. PMID 26177443.

Further reading

• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". J. Biol. Chem. 279 (45): 47242–53. doi:10.1074/jbc.M406644200. PMID 15308636.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Nishikawa M, Kira Y, Yabunaka Y, Inoue M (2007). "Identification and characterization of endoplasmic reticulum-associated protein, ERp43". Gene. 386 (1–2): 42–51. doi:10.1016/j.gene.2006.06.030. PMID 17020792.