ERAF

Alpha-hemoglobin-stabilizing protein is a protein that in humans is encoded by the ERAF gene.[3][4][5]

AHSP
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1W09, 1W0A, 1W0B, 1XZY, 1Y01, 1Z8U, 3IA3, 3OVU
Identifiers
Aliases	AHSP, EDRF, ERAF, alpha hemoglobin stabilizing protein
External IDs	OMIM: 605821 HomoloGene: 9605 GeneCards: AHSP
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p11.2 Start 31,527,900 bp[1] End 31,528,803 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • unfolded protein binding • hemoglobin binding • GO:0001948 protein binding Cellular component • cytoplasm • hemoglobin complex Biological process • protein stabilization • protein folding • erythrocyte differentiation • hemoglobin metabolic process • haematopoiesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51327	n/a
Ensembl	ENSG00000169877	n/a
UniProt	Q9NZD4	n/a
RefSeq (mRNA)	NM_016633 NM_001318221 NM_001318222	n/a
RefSeq (protein)	NP_001305150 NP_001305151 NP_057717	n/a
Location (UCSC)	Chr 16: 31.53 – 31.53 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000169877 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Miele G, Manson J, Clinton M (Mar 2001). "A novel erythroid-specific marker of transmissible spongiform encephalopathies". Nat Med. 7 (3): 361–4. doi:10.1038/85515. PMID 11231637.
4. Kihm AJ, Kong Y, Hong W, Russell JE, Rouda S, Adachi K, Simon MC, Blobel GA, Weiss MJ (Jun 2002). "An abundant erythroid protein that stabilizes free alpha-haemoglobin". Nature. 417 (6890): 758–63. doi:10.1038/nature00803. PMID 12066189.
5. "Entrez Gene: ERAF erythroid associated factor".

Further reading

• Florio P, Rossi M, Sigurdardottir M, et al. (2004). "Paracrine regulation of endometrial function: interaction between progesterone and corticotropin-releasing factor (CRF) and activin A". Steroids. 68 (10–13): 801–7. doi:10.1016/S0039-128X(03)00137-5. PMID 14667971.
• Weiss MJ, Zhou S, Feng L, et al. (2006). "Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia". Ann. N. Y. Acad. Sci. 1054: 103–17. doi:10.1196/annals.1345.013. PMID 16339656.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Gell D, Kong Y, Eaton SA, et al. (2002). "Biophysical characterization of the alpha-globin binding protein alpha-hemoglobin stabilizing protein". J. Biol. Chem. 277 (43): 40602–9. doi:10.1074/jbc.M206084200. PMID 12192002.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Viprakasit V, Tanphaichitr VS, Chinchang W, et al. (2004). "Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia". Blood. 103 (9): 3296–9. doi:10.1182/blood-2003-11-3957. PMID 14715623.
• Baudin-Creuza V, Vasseur-Godbillon C, Pato C, et al. (2004). "Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state". J. Biol. Chem. 279 (35): 36530–3. doi:10.1074/jbc.M405389200. PMID 15220346.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gallagher PG, Liem RI, Wong E, et al. (2006). "GATA-1 and Oct-1 are required for expression of the human alpha-hemoglobin-stabilizing protein gene". J. Biol. Chem. 280 (47): 39016–23. doi:10.1074/jbc.M506062200. PMID 16186125.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Hamdane D, Vasseur-Godbillon C, Baudin-Creuza V, et al. (2007). "Reversible hexacoordination of alpha-hemoglobin-stabilizing protein (AHSP)/alpha-hemoglobin Versus pressure. Evidence for protection of the alpha-chains by their chaperone". J. Biol. Chem. 282 (9): 6398–404. doi:10.1074/jbc.M610543200. PMID 17194704.