EPN2

Epsin-2 is a protein that in humans is encoded by the EPN2 gene.[5][6]

EPN2
Identifiers
Aliases	EPN2, EHB21, epsin 2
External IDs	OMIM: 607263 MGI: 1333766 HomoloGene: 40710 GeneCards: EPN2
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 19,215,615 bp[1] End 19,336,715 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B2 Start 61,517,249 bp[2] End 61,579,687 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • lipid binding • cadherin binding Cellular component • cytoplasm • intracellular membrane-bounded organelle • cytoplasmic vesicle • clathrin-coated vesicle • clathrin coat of endocytic vesicle • cytosol Biological process • endocytosis • membrane organization • negative regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of Notch signaling pathway • negative regulation of sprouting angiogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22905	13855
Ensembl	ENSG00000072134	ENSMUSG00000001036
UniProt	O95208	Q8CHU3
RefSeq (mRNA)	NM_148921 NM_001102664 NM_014964	NM_001252188 NM_001252189 NM_010148 NM_001362585 NM_001362586 NM_001362587
RefSeq (protein)	NP_001096134 NP_055779 NP_683723	NP_001239117 NP_001239118 NP_034278 NP_001349514 NP_001349515 NP_001349516
Location (UCSC)	Chr 17: 19.22 – 19.34 Mb	Chr 11: 61.52 – 61.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000072134 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001036 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P (Dec 1999). "The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module". J Biol Chem. 274 (48): 33959–65. doi:10.1074/jbc.274.48.33959. PMID 10567358.
6. "Entrez Gene: EPN2 epsin 2".

Further reading

• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein–protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
• Yamabhai M, Hoffman NG, Hardison NL, et al. (1998). "Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains". J. Biol. Chem. 273 (47): 31401–7. doi:10.1074/jbc.273.47.31401. PMID 9813051.
• Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
• Ford MG, Mills IG, Peter BJ, et al. (2002). "Curvature of clathrin-coated pits driven by epsin". Nature. 419 (6905): 361–6. doi:10.1038/nature01020. PMID 12353027.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hussain NK, Yamabhai M, Bhakar AL, et al. (2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". J. Biol. Chem. 278 (31): 28823–30. doi:10.1074/jbc.M300995200. PMID 12750376.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.