EMCN

Endomucin is a protein that in humans is encoded by the EMCN gene.[5][6][7] Endomucin is a marker for endothelial cells[8] and hematopoietic stem cells.[9]

EMCN
Identifiers
Aliases	EMCN, EMCN2, MUC14, endomucin
External IDs	OMIM: 608350 MGI: 1891716 HomoloGene: 9438 GeneCards: EMCN
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q24 Start 100,395,341 bp[1] End 100,880,126 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G3 Start 137,341,067 bp[2] End 137,432,185 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51705	59308
Ensembl	ENSG00000164035	ENSMUSG00000054690
UniProt	Q9ULC0	Q9R0H2
RefSeq (mRNA)	NM_001159694 NM_016242	NM_001163522 NM_016885
RefSeq (protein)	NP_001153166 NP_057326	NP_001156994 NP_058581
Location (UCSC)	Chr 4: 100.4 – 100.88 Mb	Chr 3: 137.34 – 137.43 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.[5][7]

References

1. GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125.
6. Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
7. "Entrez Gene: EMCN endomucin".
8. Liu C, et al. (2001). "Human Endomucin Is an Endothelial Marker". Biochemical and Biophysical Research Communications. 288: 129–136. doi:10.1006/bbrc.2001.5737. PMID 11594763.
9. Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483–1492. doi:10.1084/jem.20051325. PMC 2213340. PMID 16314436.

Further reading

• Li G, Miles A, Line A, Rees RC (March 2004). "Identification of tumour antigens by serological analysis of cDNA expression cloning". Cancer Immunology, Immunotherapy. 53 (3): 139–43. doi:10.1007/s00262-003-0471-y. PMID 14722670.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, Böcker W, Vestweber D (May 2002). "Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope". The American Journal of Pathology. 160 (5): 1669–81. doi:10.1016/S0002-9440(10)61114-5. PMC 1850881. PMID 12000719.
• Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (June 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–30. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
• Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D, Vestweber D (December 2002). "Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin". The Journal of Investigative Dermatology. 119 (6): 1388–93. doi:10.1046/j.1523-1747.2002.19647.x. PMID 12485444.
• Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M, Noda M, Kannagi R, Hirata T, Murai T, Fukuda M, Miyasaka M (September 2004). "Endomucin, a sialomucin expressed in high endothelial venules, supports L-selectin-mediated rolling". International Immunology. 16 (9): 1265–74. doi:10.1093/intimm/dxh128. PMID 15249540.
• Reckzeh K.; Kizilkaya H.; Søgaard Helbo A.; Estruch Alrich M.; et al. (2018). "Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin". Blood Advances. 2 (13): 1628–1632. doi:10.1182/bloodadvances.2018015743. PMC 6039657. PMID 29986855.</ref>