ELP3

Elongator complex protein 3, also named KAT9, is a protein that in humans is encoded by the ELP3 gene.[5][6] ELP3 is the catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. ELP3 supports the migration and branching of projection neurons through acetylation of alpha-tubulin in the developing cerebral cortex.[7] In mammals, ELP3 is important for paternal DNA demethylation after fertilization.[8] ELP3 is potentially involved in cellular redox homeostasis by mediating the acetylation of glucose-6-phosphate dehydrogenase.[9] Besides, ELP3 may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.

ELP3
Identifiers
Aliases	ELP3, KAT9, elongator acetyltransferase complex subunit 3
External IDs	OMIM: 612722 MGI: 1921445 HomoloGene: 7105 GeneCards: ELP3
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.1 Start 28,089,673 bp[1] End 28,191,156 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 65,530,449 bp[2] End 65,593,075 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • RNA polymerase II core binding • iron-sulfur cluster binding • H4 histone acetyltransferase activity • H3 histone acetyltransferase activity • metal ion binding • histone acetyltransferase activity • phosphorylase kinase regulator activity • GO:0001948 protein binding • catalytic activity • transferase activity, transferring acyl groups • acetyltransferase activity Cellular component • cytoplasm • Elongator holoenzyme complex • nucleolus • histone acetyltransferase complex • transcription elongation factor complex • cell nucleus Biological process • regulation of transcription, DNA-templated • positive regulation of cell migration • regulation of transcription from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • neuron migration • transcription, DNA-templated • nervous system development • central nervous system development • histone H3 acetylation • histone H4 acetylation • regulation of protein kinase activity • tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation • histone acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55140	74195
Ensembl	ENSG00000134014	ENSMUSG00000022031
UniProt	Q9H9T3	Q9CZX0
RefSeq (mRNA)	NM_001284220 NM_001284222 NM_001284224 NM_001284225 NM_001284226 NM_018091	NM_001253812 NM_028811
RefSeq (protein)	NP_001271149 NP_001271151 NP_001271153 NP_001271154 NP_001271155 NP_060561	NP_001240741 NP_083087
Location (UCSC)	Chr 8: 28.09 – 28.19 Mb	Chr 14: 65.53 – 65.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000134014 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022031 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ (Jan 2002). "Purification and characterization of the human elongator complex". J Biol Chem. 277 (4): 3047–52. doi:10.1074/jbc.M110445200. PMID 11714725.
6. "Entrez Gene: ELP3 elongation protein 3 homolog (S. cerevisiae)".
7. Creppe C, Malinouskaya L, Volvert ML, Gillard M, Close P, Malaise O, Laguesse S, Cornez I, Rahmouni S, Ormenese S, Belachew S, Malgrange B, Chapelle JP, Siebenlist U, Moonen G, Chariot A, Nguyen L (Feb 2009). "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin". Cell. 136 (3): 551–64. doi:10.1016/j.cell.2008.11.043. PMID 19185337.
8. Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y (Jan 2010). "A role for the elongator complex in zygotic paternal genome demethylation". Nature. 463 (7280): 554–8. doi:10.1038/nature08732. PMC 2834414. PMID 20054296.
9. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D (Jun 2014). "Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress". The EMBO Journal. 33 (12): 1304–20. doi:10.1002/embj.201387224. PMC 4194121. PMID 24769394.

Further reading

• Rengo F, Brevetti G, Piscione F, et al. (1977). "[Behavior of some metabolic parameters during post-ischemic and post-contraction vasodilation in normal subjects]". Bollettino della Società italiana di cardiologia. 20 (12): 1801–6. PMID 10936.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Ninomiya Y, Okada M, Kotomura N, et al. (1996). "Genomic organization and isoforms of the mouse ELP gene". J. Biochem. 118 (2): 380–9. doi:10.1093/oxfordjournals.jbchem.a124918. PMID 8543574.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241–6. doi:10.1073/pnas.251672198. PMC 122174. PMID 11818576.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kouskouti A, Talianidis I (2005). "Histone modifications defining active genes persist after transcriptional and mitotic inactivation". EMBO J. 24 (2): 347–57. doi:10.1038/sj.emboj.7600516. PMC 545808. PMID 15616580.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Han Q, Hou X, Su D, et al. (2007). "hELP3 subunit of the Elongator complex regulates the transcription of HSP70 gene in human cells". Acta Biochim. Biophys. Sin. (Shanghai). 39 (6): 453–61. doi:10.1111/j.1745-7270.2007.00293.x. PMID 17558451.