ELL3

Elongation factor RNA polymerase II-like 3 is a protein that in humans is encoded by the ELL3 gene.[5]

ELL3
Identifiers
Aliases	ELL3, ELL3 (gene), elongation factor for RNA polymerase II 3
External IDs	OMIM: 609885 MGI: 2673679 HomoloGene: 11859 GeneCards: ELL3
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.3 Start 43,772,605 bp[1] End 43,777,315 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 121,439,010 bp[2] End 121,444,278 bp[2]
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • nucleolus • transcription elongation factor complex • cell nucleus • nucleoplasm Biological process • positive regulation of DNA-templated transcription, elongation • positive regulation of neurogenesis • positive regulation of neural precursor cell proliferation • transcription elongation from RNA polymerase II promoter • regulation of epithelial to mesenchymal transition • DNA-templated transcription, elongation • regulation of transcription, DNA-templated • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • transcription from RNA polymerase II promoter • spermatogenesis • positive regulation of transcription from RNA polymerase II promoter • stem cell differentiation • transcription, DNA-templated • negative regulation of signal transduction by p53 class mediator • snRNA transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80237	269344
Ensembl	ENSG00000128886	ENSMUSG00000027246
UniProt	Q9HB65	Q80VR2
RefSeq (mRNA)	NM_025165	NM_145973
RefSeq (protein)	NP_079441	NP_666085
Location (UCSC)	Chr 15: 43.77 – 43.78 Mb	Chr 2: 121.44 – 121.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000128886 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027246 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Elongation factor RNA polymerase II-like 3".

Further reading

• Takahashi H, Parmely TJ, Sato S, Tomomori-Sato C, Banks CA, Kong SE, Szutorisz H, Swanson SK, Martin-Brown S, Washburn MP, Florens L, Seidel CW, Lin C, Smith ER, Shilatifard A, Conaway RC, Conaway JW (July 2011). "Human mediator subunit MED26 functions as a docking site for transcription elongation factors". Cell. 146 (1): 92–104. doi:10.1016/j.cell.2011.06.005. PMC 3145325. PMID 21729782.
• Park G, Gong Z, Chen J, Kim JE (April 2010). "Characterization of the DOT1L network: implications of diverse roles for DOT1L". The Protein Journal. 29 (3): 213–23. doi:10.1007/s10930-010-9242-8. PMID 20431927.
• Miller T, Williams K, Johnstone RW, Shilatifard A (October 2000). "Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3". The Journal of Biological Chemistry. 275 (41): 32052–6. doi:10.1074/jbc.M005175200. PMID 10882741.
• Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y (May 2009). "Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins". Proteomics. 9 (9): 2444–56. doi:10.1002/pmic.200800738. PMID 19343720.