ELAV-like protein 2

ELAV-like protein 2 is a protein that in humans is encoded by the ELAVL2 gene.[4][5]

ELAVL2
Identifiers
Aliases	ELAVL2, HEL-N1, HELN1, HUB, ELAV like neuron-specific RNA binding protein 2, ELAV like RNA binding protein 2
External IDs	OMIM: 601673 MGI: 1100887 HomoloGene: 20930 GeneCards: ELAVL2
Gene location (Mouse) Chr. Chromosome 4 (mouse)[1] Band 4 C5|4 42.36 cM Start 91,250,763 bp[1] End 91,400,785 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • mRNA 3'-UTR binding • nucleic acid binding • RNA binding Cellular component • nucleoplasm Biological process • regulation of transcription, DNA-templated • mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1993	15569
Ensembl	n/a	ENSMUSG00000008489
UniProt	Q12926	Q60899
RefSeq (mRNA)	NM_001171195 NM_001171197 NM_004432	NM_001177883 NM_010486 NM_207685 NM_207686 NM_001347149 NM_001357188 NM_001357189
RefSeq (protein)	NP_001164666 NP_001164668 NP_004423 NP_001338384 NP_001338385 NP_001338386 NP_001338387 NP_001338388 NP_001338389 NP_001338390 NP_001338391 NP_001338392 NP_001338393 NP_001338394 NP_001338395 NP_001338396 NP_001338397 NP_001338398 NP_001338399 NP_001338400 NP_001338401 NP_001338402 NP_001338403 NP_001338404 NP_001338405 NP_001338406 NP_001338407	NP_001171354 NP_001334078 NP_034616 NP_997568 NP_997569 NP_001344117 NP_001344118 NP_001361165 NP_001361166 NP_001361167 NP_001361625
Location (UCSC)	n/a	Chr 4: 91.25 – 91.4 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCm38: Ensembl release 89: ENSMUSG00000008489 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Han J, Knops JF, Longshore JW, King PH (Feb 1997). "Localization of human elav-like neuronal protein 1 (Hel-N1) on chromosome 9p21 by chromosome microdissection polymerase chain reaction and fluorescence in situ hybridization". Genomics. 36 (1): 189–91. doi:10.1006/geno.1996.0444. PMID 8812435.
5. "Entrez Gene: ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)".

Further reading

• Gao FB, Carson CC, Levine T, Keene JD (1994). "Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 11207–11. doi:10.1073/pnas.91.23.11207. PMC 45196. PMID 7972035.
• King PH, Levine TD, Fremeau RT, Keene JD (1994). "Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor". J. Neurosci. 14 (4): 1943–52. doi:10.1523/JNEUROSCI.14-04-01943.1994. PMC 6577146. PMID 8158249.
• Gao FB, Keene JD (1997). "Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation". J. Cell Sci. 109 (3): 579–89. PMID 8907704.
• Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yano M, Okano HJ, Okano H (2005). "Involvement of Hu and heterogeneous nuclear ribonucleoprotein K in neuronal differentiation through p21 mRNA post-transcriptional regulation". J. Biol. Chem. 280 (13): 12690–9. doi:10.1074/jbc.M411119200. PMID 15671036.