ELAV-like protein 1

ELAV-like protein 1 or HuR (human antigen R) is a protein that in humans is encoded by the ELAVL1 gene.[5][6]

ELAVL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HI9, 4ED5, 4EGL, 4FXV
Identifiers
Aliases	ELAVL1, ELAV1, HUR, Hua, MelG, ELAV like RNA binding protein 1
External IDs	OMIM: 603466 MGI: 1100851 HomoloGene: 20367 GeneCards: ELAVL1
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,958,573 bp[1] End 8,005,659 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 2.0 cM Start 4,285,382 bp[2] End 4,325,413 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • mRNA 3'-UTR binding • GO:0001948 protein binding • RNA binding • nucleic acid binding • double-stranded RNA binding • protein kinase binding • mRNA binding • AU-rich element binding • mRNA 3'-UTR AU-rich region binding • miRNA binding Cellular component • cytoplasm • cytosol • membrane • nucleoplasm • cell nucleus • ribonucleoprotein • cytoplasmic stress granule • postsynapse • glutamatergic synapse Biological process • regulation of mRNA stability • regulation of stem cell population maintenance • positive regulation of translation • multicellular organism development • mRNA stabilization • 3'-UTR-mediated mRNA stabilization • mRNA splicing, via spliceosome • negative regulation of gene silencing by miRNA • protein homooligomerization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1994	15568
Ensembl	ENSG00000066044	ENSMUSG00000040028
UniProt	Q15717	P70372
RefSeq (mRNA)	NM_001419	NM_010485
RefSeq (protein)	NP_001410	NP_034615
Location (UCSC)	Chr 19: 7.96 – 8.01 Mb	Chr 8: 4.29 – 4.33 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.[7]

See also

• RNA-Binding Protein

References

1. GRCh38: Ensembl release 89: ENSG00000066044 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040028 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein". J Biol Chem. 271 (14): 8144–8151. doi:10.1074/jbc.271.14.8144. PMID 8626503.
6. Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet. 99 (1): 32–33. doi:10.1007/s004390050305. PMID 9003489.
7. "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)".

Further reading

• Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH (2003). "Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR". Cancer Res. 63 (14): 4181–7. PMID 12874024.
• Abdelmohsen K, Lal A, Kim HH, Gorospe M (2007). "Posttranscriptional orchestration of an anti-apoptotic program by HuR". Cell Cycle. 6 (11): 1288–92. doi:10.4161/cc.6.11.4299. PMID 17534146.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–268. doi:10.1006/bbrc.1999.0282. PMID 10079173.
• Wang W, Furneaux H, Cheng H, et al. (2000). "HuR regulates p21 mRNA stabilization by UV light". Mol. Cell. Biol. 20 (3): 760–769. doi:10.1128/MCB.20.3.760-769.2000. PMC 85192. PMID 10629032.
• Blaxall BC, Pellett AC, Wu SC, et al. (2000). "Purification and characterization of beta-adrenergic receptor mRNA-binding proteins". J. Biol. Chem. 275 (6): 4290–4297. doi:10.1074/jbc.275.6.4290. PMID 10660597.
• Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–4772. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
• Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–390. doi:10.1006/viro.2000.0461. PMID 10964780.
• Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
• Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–1901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309.
• Goldberg-Cohen I, Furneauxb H, Levy AP (2002). "A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR". J. Biol. Chem. 277 (16): 13635–13640. doi:10.1074/jbc.M108703200. PMID 11834731.
• Wang W, Fan J, Yang X, et al. (2002). "AMP-activated kinase regulates cytoplasmic HuR". Mol. Cell. Biol. 22 (10): 3425–3436. doi:10.1128/MCB.22.10.3425-3436.2002. PMC 133799. PMID 11971974.
• Yeap BB, Voon DC, Vivian JP, et al. (2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA". J. Biol. Chem. 277 (30): 27183–27192. doi:10.1074/jbc.M202883200. PMID 12011088.
• Li H, Park S, Kilburn B, et al. (2003). "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase". J. Biol. Chem. 277 (47): 44623–44630. doi:10.1074/jbc.M206187200. PMID 12237300.
• Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization". Mol. Cell. Biol. 22 (20): 7268–7278. doi:10.1128/MCB.22.20.7268-7278.2002. PMC 139819. PMID 12242302.
• Giles KM, Daly JM, Beveridge DJ, et al. (2003). "The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein". J. Biol. Chem. 278 (5): 2937–2946. doi:10.1074/jbc.M208439200. PMID 12431987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang W, Yang X, López de Silanes I, et al. (2003). "Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function". J. Biol. Chem. 278 (29): 27016–27023. doi:10.1074/jbc.M300318200. PMID 12730239.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human ELAV-like protein 1

This article incorporates text from the United States National Library of Medicine (), which is in the public domain.