ELAV-like protein 3

ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.[5][6]

ELAVL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D8Z, 1D9A, 1FNX
Identifiers
Aliases	ELAVL3, HUC, HUCL, PLE21, ELAV like neuron-specific RNA binding protein 3, ELAV like RNA binding protein 3
External IDs	OMIM: 603458 MGI: 109157 HomoloGene: 31035 GeneCards: ELAVL3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 11,451,326 bp[1] End 11,481,046 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 8.07 cM Start 22,015,005 bp[2] End 22,052,023 bp[2]
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1995	15571
Ensembl	ENSG00000196361	ENSMUSG00000003410
UniProt	Q14576	Q60900
RefSeq (mRNA)	NM_001420 NM_032281	NM_010487
RefSeq (protein)	NP_001411 NP_115657	NP_034617
Location (UCSC)	Chr 19: 11.45 – 11.48 Mb	Chr 9: 22.02 – 22.05 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000196361 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003410 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
6. "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
• Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
• Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–8. doi:10.1006/bbrc.1999.0282. PMID 10079173.
• Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma". Biochem. Biophys. Res. Commun. 199 (3): 1200–8. doi:10.1006/bbrc.1994.1358. PMID 7511893.