EIF4EBP3

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.[4][5]

EIF4EBP3
Identifiers
Aliases	EIF4EBP3, 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDs	OMIM: 603483 MGI: 1270847 HomoloGene: 37841 GeneCards: EIF4EBP3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.3 Start 140,547,662 bp[1] End 140,549,576 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • eukaryotic initiation factor 4E binding • translation repressor activity Cellular component • cytoplasm • eukaryotic translation initiation factor 4F complex • membrane Biological process • negative regulation of translation • regulation of translation • negative regulation of translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8637	108112
Ensembl	ENSG00000243056	n/a
UniProt	O60516	Q80VV3
RefSeq (mRNA)	NM_003732	NM_201256
RefSeq (protein)	NP_003723	NP_957708
Location (UCSC)	Chr 5: 140.55 – 140.55 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.[5]

Interactions

EIF4EBP3 has been shown to interact with EIF4E.[4][6]

References

1. GRCh38: Ensembl release 89: ENSG00000243056 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. PMID 9593750.
5. "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
6. Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586.

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
• Poulin F, Brueschke A, Sonenberg N (2003). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi:10.1074/jbc.M310761200. PMID 14557257.
• Ferguson G, Mothe-Satney I, Lawrence JC (2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. doi:10.1074/jbc.M307949200. PMID 14507920.
• Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586.