EIF4EBP2

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.[5][6][7]

EIF4EBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MX4, 3AM7
Identifiers
Aliases	EIF4EBP2, 4EBP2, PHASII, eukaryotic translation initiation factor 4E binding protein 2
External IDs	OMIM: 602224 MGI: 109198 HomoloGene: 3022 GeneCards: EIF4EBP2
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 70,404,145 bp[1] End 70,428,618 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B4|10 32.21 cM Start 61,428,491 bp[2] End 61,452,661 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • eukaryotic initiation factor 4E binding • translation repressor activity • translation initiation factor activity Cellular component • cytoplasm • postsynapse • intracellular Biological process • social organism behavior • insulin receptor signaling pathway • modulation of chemical synaptic transmission • negative regulation of translation • memory • TOR signaling • protein biosynthesis • cAMP-mediated signaling • regulation of translation • negative regulation of translational initiation • regulation of synaptic plasticity • translational initiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1979	13688
Ensembl	ENSG00000148730	ENSMUSG00000020091
UniProt	Q13542	P70445
RefSeq (mRNA)	NM_004096	NM_010124
RefSeq (protein)	NP_004087 NP_004087.1	NP_034254
Location (UCSC)	Chr 10: 70.4 – 70.43 Mb	Chr 10: 61.43 – 61.45 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins.[8]

Interactions

EIF4EBP2 has been shown to interact with EIF4E.[5][9]

References

1. GRCh38: Ensembl release 89: ENSG00000148730 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020091 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N (October 1994). "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Nature. 371 (6500): 762–7. doi:10.1038/371762a0. PMID 7935836.
6. Tsukiyama-Kohara K, Vidal SM, Gingras AC, Glover TW, Hanash SM, Heng H, Sonenberg N (December 1996). "Tissue distribution, genomic structure, and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2". Genomics. 38 (3): 353–63. doi:10.1006/geno.1996.0638. PMID 8975712.
7. "Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2".
8. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N (January 2013). "Autism-related deficits via dysregulated eIF4E-dependent translational control". Nature. 493 (7432): 371–7. doi:10.1038/nature11628. PMC 4133997. PMID 23172145. Lay summary – Nature Magazine.
9. Mader S, Lee H, Pause A, Sonenberg N (September 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology. 15 (9): 4990–7. doi:10.1128/mcb.15.9.4990. PMC 230746. PMID 7651417.

Further reading

• Lin TA, Lawrence JC (November 1996). "Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes". The Journal of Biological Chemistry. 271 (47): 30199–204. doi:10.1074/jbc.271.47.30199. PMID 8939971.
• Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC, Houghton PJ (April 2002). "4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin". The Journal of Biological Chemistry. 277 (16): 13907–17. doi:10.1074/jbc.M110782200. PMID 11847216.
• Shenberger JS, Adams MH, Zimmer SG (August 2002). "Oxidant-induced hypertrophy of A549 cells is accompanied by alterations in eukaryotic translation initiation factor 4E and 4E-binding protein-1". American Journal of Respiratory Cell and Molecular Biology. 27 (2): 250–6. doi:10.1165/ajrcmb.27.2.4785. PMID 12151318.
• Ferguson G, Mothe-Satney I, Lawrence JC (November 2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". The Journal of Biological Chemistry. 278 (48): 47459–65. doi:10.1074/jbc.M307949200. PMID 14507920.
• Joshi B, Cameron A, Jagus R (June 2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.