EID1

EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene.[4][5][6]

EID1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NUF
Identifiers
Aliases	EID1, C15orf3, CRI1, EID-1, IRO45620, PTD014, RBP21, PNAS-22, EP300 interacting inhibitor of differentiation 1
External IDs	OMIM: 605894 MGI: 1889651 HomoloGene: 49376 GeneCards: EID1
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q21.1 Start 48,878,134 bp[1] End 48,880,173 bp[1]
Gene ontology Molecular function • GO:0001948 protein binding • histone acetyltransferase binding • GO:0001106 transcription corepressor activity • histone acetyltransferase regulator activity Cellular component • cytoplasm • cell nucleus • nucleoplasm • cytoplasmic ribonucleoprotein granule Biological process • cell cycle • cell differentiation • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • regulation of histone acetylation • regulation of cell differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23741	58521
Ensembl	ENSG00000255302	n/a
UniProt	Q9Y6B2	Q9DCR4
RefSeq (mRNA)	NM_014335	NM_025613
RefSeq (protein)	NP_055150	NP_079889
Location (UCSC)	Chr 15: 48.88 – 48.88 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

EID1 has been shown to interact with EP300[5][7] and Retinoblastoma protein.[5][7]

References

1. GRCh38: Ensembl release 89: ENSG00000255302 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Carim L, Sumoy L, Andreu N, Estivill X, Escarceller M (June 2000). "Identification and expression analysis of C15orf3, a novel gene on chromosome 15q21.1→q21.2". Cytogenet Cell Genet. 88 (3–4): 330–2. doi:10.1159/000015523. PMID 10828624.
5. MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). "A novel Rb- and p300-binding protein inhibits transactivation by MyoD". Mol Cell Biol. 20 (23): 8903–15. doi:10.1128/MCB.20.23.8903-8915.2000. PMC 86545. PMID 11073990.
6. "Entrez Gene: EID1 EP300 interacting inhibitor of differentiation 1".
7. Miyake, S; Sellers W R; Safran M; Li X; Zhao W; Grossman S R; Gan J; DeCaprio J A; Adams P D; Kaelin W G (December 2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. ISSN 0270-7306. PMC 86544. PMID 11073989.

Further reading

• Ghosh AK, Varga J (2007). "The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis". J. Cell. Physiol. 213 (3): 663–71. doi:10.1002/jcp.21162. PMID 17559085.
• Margottin F, Bour SP, Durand H, et al. (1998). "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif". Mol. Cell. 1 (4): 565–74. doi:10.1016/S1097-2765(00)80056-8. PMID 9660940.
• Miyake S, Sellers WR, Safran M, et al. (2000). "Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle". Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/MCB.20.23.8889-8902.2000. PMC 86544. PMID 11073989.
• Wen H, Ao S (2001). "Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein". Gene. 263 (1–2): 85–92. doi:10.1016/S0378-1119(00)00585-0. PMID 11223246.
• Båvner A, Johansson L, Toresson G, et al. (2002). "A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP". EMBO Rep. 3 (5): 478–84. doi:10.1093/embo-reports/kvf087. PMC 1084100. PMID 11964378.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ledl A, Schmidt D, Müller S (2005). "Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor". Oncogene. 24 (23): 3810–8. doi:10.1038/sj.onc.1208539. PMID 15806172.
• Krützfeldt M, Ellis M, Weekes DB, et al. (2005). "Selective ablation of retinoblastoma protein function by the RET finger protein". Mol. Cell. 18 (2): 213–24. doi:10.1016/j.molcel.2005.03.009. PMID 15837424.
• Benevolenskaya EV, Murray HL, Branton P, et al. (2005). "Binding of pRB to the PHD protein RBP2 promotes cellular differentiation". Mol. Cell. 18 (6): 623–35. doi:10.1016/j.molcel.2005.05.012. PMID 15949438.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.