EGOT (gene)
EGOT, also known as Eosinophil Granule Ontogeny (EGO)† Transcript (non-protein coding),[3] is a human gene at 3p26.1 that produces a long noncoding RNA molecule. EGOT is nested within an intron of the inositol triphosphate receptor type 1 (ITPR1) gene. The EGOT transcript is expressed during eosinophil development and is possibly involved in regulating eosinophil granule protein expression.[3] Comparison of EGO-B, the spliced isoform, suggests EGOT may be conserved across placental mammals.[4]
| EGOT | |||||||||||||||||||||||||
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| Aliases | EGOT, EGO, NCRNA00190, eosinophil granule ontogeny transcript (non-protein coding), eosinophil granule ontogeny transcript | ||||||||||||||||||||||||
| External IDs | OMIM: 611662 GeneCards: EGOT | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 3: 4.75 – 4.75 Mb | n/a | |||||||||||||||||||||||
| PubMed search | [2] | n/a | |||||||||||||||||||||||
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†Originally published as EGO but renamed as EGOT because 'EGO' is a real word and is therefore problematic when searching the scientific literature.[5]
References
- GRCh38: Ensembl release 89: ENSG00000235947 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Wagner LA, Christensen CJ, Dunn DM, et al. (June 2007). "EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression". Blood. 109 (12): 5191–5198. doi:10.1182/blood-2006-06-027987. PMC 1890841. PMID 17351112.
- Rose D, Stadler PF (October 2011). "Molecular evolution of the non-coding eosinophil granule ontogeny transcript". Front Genet. 2. doi:10.3389/fgene.2011.00069. PMC 3268622. PMID 22303364.
- Wright, MW (Apr 9, 2014). "A short guide to long non-coding RNA gene nomenclature". Human Genomics. 8: 7. doi:10.1186/1479-7364-8-7. PMC 4021045. PMID 24716852.
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