EDEM1

ER degradation-enhancing alpha-mannosidase-like 1 is an enzyme that in humans is encoded by the EDEM1 gene.[5][6]

EDEM1
Identifiers
Aliases	EDEM1, EDEM, ER degradation enhancing alpha-mannosidase like protein 1
External IDs	OMIM: 607673 MGI: 2180139 HomoloGene: 33836 GeneCards: EDEM1
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p26.1 Start 5,187,646 bp[1] End 5,219,958 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E2 Start 108,828,641 bp[2] End 108,859,356 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • misfolded protein binding • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • GO:0001948 protein binding • catalytic activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum • endoplasmic reticulum quality control compartment • Golgi membrane • aggresome Biological process • N-glycan processing • positive regulation of retrograde protein transport, ER to cytosol • trimming of terminal mannose on C branch • IRE1-mediated unfolded protein response • response to unfolded protein • ubiquitin-dependent glycoprotein ERAD pathway • mannose trimming involved in glycoprotein ERAD pathway • ubiquitin-dependent ERAD pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9695	192193
Ensembl	ENSG00000134109	ENSMUSG00000030104
UniProt	Q92611	Q925U4
RefSeq (mRNA)	NM_014674	NM_138677
RefSeq (protein)	NP_055489	NP_619618
Location (UCSC)	Chr 3: 5.19 – 5.22 Mb	Chr 6: 108.83 – 108.86 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000134109 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030104 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Molinari M, Calanca V, Galli C, Lucca P, Paganetti P (Feb 2003). "Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle". Science. 299 (5611): 1397–400. doi:10.1126/science.1079474. PMID 12610306.
6. "Entrez Gene: EDEM1 ER degradation enhancer, mannosidase alpha-like 1".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Hosokawa N, Wada I, Hasegawa K, et al. (2001). "A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation". EMBO Rep. 2 (5): 415–22. doi:10.1093/embo-reports/kve084. PMC 1083879. PMID 11375934.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Oda Y, Hosokawa N, Wada I, Nagata K (2003). "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin". Science. 299 (5611): 1394–7. doi:10.1126/science.1079181. PMID 12610305.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Olivari S, Galli C, Alanen H, et al. (2005). "A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation". J. Biol. Chem. 280 (4): 2424–8. doi:10.1074/jbc.C400534200. PMID 15579471.
• Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
• Hosokawa N, Wada I, Natsuka Y, Nagata K (2006). "EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin". Genes Cells. 11 (5): 465–76. doi:10.1111/j.1365-2443.2006.00957.x. PMID 16629899.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Zuber C, Cormier JH, Guhl B, et al. (2007). "EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4407–12. doi:10.1073/pnas.0700154104. PMC 1810509. PMID 17360537.