EBF1

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.[5][6][7]

EBF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LYR, 3MQI
Identifiers
Aliases	EBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDs	OMIM: 164343 MGI: 95275 HomoloGene: 7297 GeneCards: EBF1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 158,695,916 bp[1] End 159,099,916 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.1|11 26.45 cM Start 44,617,317 bp[2] End 45,008,091 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • protein dimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • C2H2 zinc finger domain binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component • cell nucleus Biological process • multicellular organism development • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1879	13591
Ensembl	ENSG00000164330	ENSMUSG00000057098
UniProt	Q9UH73	Q07802
RefSeq (mRNA)	NM_001290360 NM_024007 NM_182708 NM_001324101 NM_001324103 NM_001324106 NM_001324107 NM_001324108 NM_001324109 NM_001324111 NM_001364155 NM_001364156 NM_001364157 NM_001364158 NM_001364159	NM_001290709 NM_001290710 NM_001290711 NM_007897
RefSeq (protein)	NP_001277289 NP_001311030 NP_001311032 NP_001311035 NP_001311036 NP_001311037 NP_001311038 NP_001311040 NP_076870 NP_874367 NP_001351084 NP_001351085 NP_001351086 NP_001351087 NP_001351088	NP_001277638 NP_001277639 NP_001277640 NP_031923 NP_001349498 NP_001349500 NP_001349503 NP_001349504 NP_001349505 NP_001349506 NP_001349507 NP_001349508
Location (UCSC)	Chr 5: 158.7 – 159.1 Mb	Chr 11: 44.62 – 45.01 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.[8][9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.[10]

Interactions

EBF1 has been shown to interact with ZNF423[11] and CREB binding protein.[12]

References

1. GRCh38: Ensembl release 89: ENSG00000164330 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057098 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
6. Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110.
7. "Entrez Gene: EBF1 early B-cell factor 1".
8. Treiber, Thomas; Mandel, Elizabeth M.; Pott, Sebastian; Györy, Ildiko; Firner, Sonja; Liu, Edison T.; Grosschedl, Rudolf (2010). "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013. PMID 20451411.
9. Hagman, James; Ramírez, Julita; Lukin, Kara (2012-01-01). "B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1". Current Topics in Microbiology and Immunology. 356: 17–38. doi:10.1007/82_2011_139. ISBN 978-3-642-24102-4. ISSN 0070-217X. PMC 3925327. PMID 21735360.
10. Schwartz, Anton M.; Putlyaeva, Lidia V.; Covich, Milica; Klepikova, Anna V.; Akulich, Kseniya A.; Vorontsov, Ilya E.; Korneev, Kirill V.; Dmitriev, Sergey E.; Polanovsky, Oleg L. (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.
11. Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. doi:10.1523/JNEUROSCI.17-11-04159.1997. PMC 6573535. PMID 9151733.
12. Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor" (PDF). Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

Further reading

• Liberg D, Sigvardsson M, Akerblad P (2002). "The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers". Mol. Cell. Biol. 22 (24): 8389–97. doi:10.1128/MCB.22.24.8389-8397.2002. PMC 139877. PMID 12446759.
• Hagman J, Gutch MJ, Lin H, Grosschedl R (1995). "EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains". EMBO J. 14 (12): 2907–16. doi:10.1002/j.1460-2075.1995.tb07290.x. PMC 398409. PMID 7796816.
• Wang MM, Reed RR (1993). "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast". Nature. 364 (6433): 121–6. doi:10.1038/364121a0. PMID 8321284.
• Hagman J, Belanger C, Travis A, Turck CW, Grosschedl R (1993). "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression". Genes Dev. 7 (5): 760–73. doi:10.1101/gad.7.5.760. PMID 8491377.
• Travis A, Hagman J, Hwang L, Grosschedl R (1993). "Purification of early-B-cell factor and characterization of its DNA-binding specificity". Mol. Cell. Biol. 13 (6): 3392–400. doi:10.1128/MCB.13.6.3392. PMC 359803. PMID 8497258.
• Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. doi:10.1523/JNEUROSCI.17-11-04159.1997. PMID 9151733.
• Gisler R, Jacobsen SE, Sigvardsson M (2000). "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse". Blood. 96 (4): 1457–64. doi:10.1182/blood.V96.4.1457. PMID 10942392.
• Gisler R, Sigvardsson M (2002). "The human V-preB promoter is a target for coordinated activation by early B cell factor and E47". J. Immunol. 168 (10): 5130–8. doi:10.4049/jimmunol.168.10.5130. PMID 11994467.
• Smith EM, Gisler R, Sigvardsson M (2002). "Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression". J. Immunol. 169 (1): 261–70. doi:10.4049/jimmunol.169.1.261. PMID 12077253.
• Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (2003). "Inhibition of p300/CBP by early B-cell factor". Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.
• Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C (2004). "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism". J. Biol. Chem. 279 (3): 1777–86. doi:10.1074/jbc.M305418200. PMID 14594818.
• Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi:10.1182/blood-2003-07-2388. PMID 14630787.
• Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M (2005). "Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development". Blood. 106 (6): 1995–2001. doi:10.1182/blood-2004-12-4744. PMID 15920012.
• Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M (2005). "Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics". Physiol. Genomics. 23 (2): 206–16. doi:10.1152/physiolgenomics.00015.2005. PMID 16106032.
• Martínez A, Mas A, de las Heras V, Arroyo R, Fernández-Arquero M, de la Concha EG, Urcelay E (2005). "Early B-cell Factor gene association with multiple sclerosis in the Spanish population". BMC Neurol. 5: 19. doi:10.1186/1471-2377-5-19. PMC 1291372. PMID 16255771.
• Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R (2007). "Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5". Mol. Cell. Biol. 27 (2): 579–94. doi:10.1128/MCB.01192-06. PMC 1800812. PMID 17101802.

External links

• FactorBook EBF1