Dodecameric protein
A dodecameric protein has a quaternary structure consisting of 12 protein subunits in a complex. Dodecameric complexes can have a number of subunit 'topologies', but typically only a few of the theoretically possible subunit arrangements are observed in protein structures.
A dodecamer (protein) is a protein complex with 12 protein subunits.
A common subunit arrangement involves a tetrahedral distribution of subunit trimers (or 3-4-point symmetry). Another observed arrangement of subunits puts two rings of six subunits side by side along the sixfold axis (or 2-6-point symmetry).
Dodecameric proteins include
- Complete gap junction channel, composed of two hexamers.
- glutamine synthetase (PDB code: 2gls)
- Dodecameric ferritin (PDB code: 1qgh)
- Aβ42 - Amyloid-beta 42
- Helicobacter pylori urease
- HHV capsid portal protein
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References
- The Protein Data Bank (PDB)
- Protein Interfaces, Surfaces and Assemblies Server (PISA) part of the PDBe.
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