Docking protein 6
Docking protein 6 is a protein that in humans is encoded by the DOK6 gene. [5]
| DOK6 | |||||||||||||||||||||||||
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| Aliases | DOK6, DOK5L, HsT3226, docking protein 6 | ||||||||||||||||||||||||
| External IDs | OMIM: 611402 MGI: 3639495 HomoloGene: 45143 GeneCards: DOK6 | ||||||||||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||||||||||
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| Location (UCSC) | Chr 18: 69.4 – 69.85 Mb | Chr 18: 89.29 – 89.77 Mb | |||||||||||||||||||||||
| PubMed search | [3] | [4] | |||||||||||||||||||||||
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Function
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).
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References
- GRCh38: Ensembl release 89: ENSG00000206052 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000073514 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Docking protein 6". Retrieved 2017-02-01.
Further reading
- Crowder RJ, Enomoto H, Yang M, Johnson EM, Milbrandt J (2004). "Dok-6, a Novel p62 Dok family member, promotes Ret-mediated neurite outgrowth". J. Biol. Chem. 279 (40): 42072–81. doi:10.1074/jbc.M403726200. PMID 15286081.
- Kurotsuchi A, Murakumo Y, Jijiwa M, Kurokawa K, Itoh Y, Kodama Y, Kato T, Enomoto A, Asai N, Terasaki H, Takahashi M (2010). "Analysis of DOK-6 function in downstream signaling of RET in human neuroblastoma cells". Cancer Sci. 101 (5): 1147–55. doi:10.1111/j.1349-7006.2010.01520.x. PMID 20210798.
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