DicF RNA

DicF RNA is a non-coding RNA that is an antisense inhibitor of cell division gene ftsZ.[1] DicF is bound by the Hfq protein which enhances its interaction with its targets. Pathogenic E. coli strains possess multiple copies of sRNA DicF in their genomes, while non-pathogenic strains do not. DicF and Hfq are both necessary to reduce FtsZ protein levels, leading to cell filamentation under anaerobic conditions.[2]

DicF RNA
Predicted secondary structure and sequence conservation of DicF
Identifiers
SymbolDicF
RfamRF00039
Other data
RNA typeGene; antisense
Domain(s)Bacteria
GO0003729
SO0000644
PDB structuresPDBe

References
  1. Faubladier M, Bouché JP (February 1994). "Division inhibition gene dicF of Escherichia coli reveals a widespread group of prophage sequences in bacterial genomes". Journal of Bacteriology. 176 (4): 1150–1156. doi:10.1128/jb.176.4.1150-1156.1994. PMC 205167. PMID 7508908.
  2. Murashko ON, Lin-Chao S (September 2017). "Escherichia coli responds to environmental changes using enolasic degradosomes and stabilized DicF sRNA to alter cellular morphology". Proceedings of the National Academy of Sciences of the United States of America. 114 (38): E8025–E8034. doi:10.1073/pnas.1703731114. PMC 5617263. PMID 28874523.

Further reading
  • Tétart F, Bouché JP (March 1992). "Regulation of the expression of the cell-cycle gene ftsZ by DicF antisense RNA. Division does not require a fixed number of FtsZ molecules". Molecular Microbiology. 6 (5): 615–620. doi:10.1111/j.1365-2958.1992.tb01508.x. PMID 1372677.
  • Bouché F, Bouché JP (July 1989). "Genetic evidence that DicF, a second division inhibitor encoded by the Escherichia coli dicB operon, is probably RNA". Molecular Microbiology. 3 (7): 991–994. doi:10.1111/j.1365-2958.1989.tb00249.x. PMID 2477663.
  • Cam K, Cuzange A, Bouché JP (July 1995). "Sigma S-dependent overexpression of ftsZ in an Escherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA". Molecular & General Genetics. 248 (2): 190–194. doi:10.1007/BF02190800. PMID 7651342.
  • Faubladier M, Cam K, Bouché JP (April 1990). "Escherichia coli cell division inhibitor DicF-RNA of the dicB operon. Evidence for its generation in vivo by transcription termination and by RNase III and RNase E-dependent processing". Journal of Molecular Biology. 212 (3): 461–471. doi:10.1016/0022-2836(90)90325-G. PMID 1691299.
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