Dextran 1

Dextran 1 is a hapten inhibitor that greatly reduces the risk for anaphylactic reactions when administering dextran.[1]

Mechanism

Dextran 1 is composed of a small fraction (1 kilodalton) of the entire dextran complex. This is enough to bind anti-dextran antibodies, but insufficient to result in the formation of immune complexes and resultant immune responses. Thereby, dextran 1 binds up antibodies towards dextran without causing the immune response, leaving less antibodies left to bind to the entire dextran complex, causing less risk of an immune response upon subsequent administration of dextran.[2]

gollark: ```Currency exchange rates from FloatRates (USD base) on 2020-10-03 3679 units, 109 prefixes, 114 nonlinear unitsYou have: 1 cubitUnknown unit 'cubit'```Troubling.
gollark: GTech™ can also set up orbital nutritional bombardment streams with food shipped from the lunar farms.
gollark: How do they get around the square cube law?
gollark: How large are these giant-children?
gollark: Interesting!

References
  1. Ljungstrom, K.; Willman, B.; Hedin, H. (1993). "Hapten inhibition of dextran anaphylaxis. Nine years of post-marketing surveillance of dextran 1". Annales Françaises d'Anesthésie et de Réanimation. 12: 219–22. doi:10.1016/S0750-7658(05)81033-0. PMID 7690207.
  2. Promiten, drug information from the Swedish official drug catalog Last updated: 2005-02-17
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.