Dermal equivalent

The dermal equivalent is an in vitro model of the dermal layer of skin. It is constructed by seeding dermal fibroblasts into a collagen gel. This gel may then be allowed to contract as a model of wound contraction. This collagen gel contraction assay may be used to screen for treatments which promote or inhibit contraction and thus affect the development of a scar. Other cell types may be incorporated into the dermal equivalent to increase the complexity of the model. For example, keratinocytes may be seeded on the surface to create a skin equivalent, or macrophages may be incorporated to model the inflammatory phase of wound healing.[1]

References

Newton, P. M; Watson, J. A; Wolowacz, R. G; Wood, E. J (2004). "Macrophages Restrain Contraction of an in Vitro Wound Healing Model". Inflammation. 28 (4): 207–214. doi:10.1023/B:IFLA.0000049045.41784.59. PMID 15673162.

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[1] Newton, P. M; Watson, J. A; Wolowacz, R. G; Wood, E. J (2004). "Macrophages Restrain Contraction of an in Vitro Wound Healing Model". Inflammation. 28 (4): 207–214. doi:10.1023/B:IFLA.0000049045.41784.59. PMID 15673162.