DYRK1B

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.[5][6]

DYRK1B
Identifiers
Aliases	DYRK1B, AOMS3, MIRK, dual specificity tyrosine phosphorylation regulated kinase 1B
External IDs	OMIM: 604556 MGI: 1330302 HomoloGene: 31253 GeneCards: DYRK1B
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 39,825,350 bp[1] End 39,834,201 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 28,179,469 bp[2] End 28,187,294 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein kinase activity • GO:0001105 transcription coactivator activity • protein serine/threonine/tyrosine kinase activity • protein serine/threonine kinase activity • protein tyrosine kinase activity • nucleotide binding • GO:0001948 protein binding • ATP binding • kinase activity Cellular component • cell nucleus Biological process • positive regulation of transcription, DNA-templated • protein phosphorylation • peptidyl-tyrosine phosphorylation • myoblast fusion • adipose tissue development • phosphorylation • autophosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9149	13549
Ensembl	ENSG00000105204 ENSG00000281320	ENSMUSG00000002409
UniProt	Q9Y463	Q9Z188
RefSeq (mRNA)	NM_004714 NM_006483 NM_006484	NM_001037957 NM_001271370 NM_010092
RefSeq (protein)	NP_004705 NP_006474 NP_006475 NP_004705.1	NP_001033046 NP_001258299 NP_034222
Location (UCSC)	Chr 19: 39.83 – 39.83 Mb	Chr 7: 28.18 – 28.19 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

DYRK1B is a member of the DYRK family of protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the catalytic domain.[6]

Interactions

DYRK1B has been shown to interact with:

• PCBD1[7] and
• RANBP9.[8]

Clinical significance

One lone missense mutation in Dyrk1B gene (R102C) was found associated with an autosomal dominant early onset Coronary Artery Disease, juvenile-onset truncal obesity, severe hypertension, and type II diabetes mellitus - seen in subjects from a nomadic group in Iran.[9]

References

1. ENSG00000281320 GRCh38: Ensembl release 89: ENSG00000105204, ENSG00000281320 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002409 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leder S, Weber Y, Altafaj X, Estivill X, Joost HG, Becker W (Feb 1999). "Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases". Biochem Biophys Res Commun. 254 (2): 474–9. doi:10.1006/bbrc.1998.9967. PMID 9918863.
6. "Entrez Gene: DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B".
7. Lim S, Jin K, Friedman E (Jul 2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.
8. Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
9. Keramati AR; et al. (2013). "Identification of a Novel Disease Gene for Early Onset Atherosclerosis, Diabetes and Metabolic Syndrome by Whole Exome Sequencing and Linkage Analysis". Circulation. 128 (22 Supplement).

Further reading

• Mercer SE, Friedman E (2006). "Mirk/Dyrk1B: a multifunctional dual-specificity kinase involved in growth arrest, differentiation, and cell survival". Cell Biochem. Biophys. 45 (3): 303–15. doi:10.1385/CBB:45:3:303. PMID 16845176.
• Lee K, Deng X, Friedman E (2000). "Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells". Cancer Res. 60 (13): 3631–7. PMID 10910078.
• Lim S, Jin K, Friedman E (2002). "Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha". J. Biol. Chem. 277 (28): 25040–6. doi:10.1074/jbc.M203257200. PMID 11980910.
• Lim S, Zou Y, Friedman E (2003). "The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase". J. Biol. Chem. 277 (51): 49438–45. doi:10.1074/jbc.M206840200. PMID 12384504.
• Zou Y, Lim S, Lee K, Deng X, Friedman E (2004). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M." J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
• Skurat AV, Dietrich AD (2004). "Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases". J. Biol. Chem. 279 (4): 2490–8. doi:10.1074/jbc.M301769200. PMID 14593110.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Deng X, Ewton DZ, Mercer SE, Friedman E (2005). "Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation". J. Biol. Chem. 280 (6): 4894–905. doi:10.1074/jbc.M411894200. PMID 15546868.
• Mercer SE, Ewton DZ, Deng X, Lim S, Mazur TR, Friedman E (2005). "Mirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblasts". J. Biol. Chem. 280 (27): 25788–801. doi:10.1074/jbc.M413594200. PMC 1201501. PMID 15851482.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Deng X, Ewton DZ, Li S, Naqvi A, Mercer SE, Landas S, Friedman E (2006). "The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma". Cancer Res. 66 (8): 4149–58. doi:10.1158/0008-5472.CAN-05-3089. PMID 16618736.
• Takahashi-Yanaga F, Mori J, Matsuzaki E, Watanabe Y, Hirata M, Miwa Y, Morimoto S, Sasaguri T (2007). "Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells". J. Biol. Chem. 281 (50): 38489–97. doi:10.1074/jbc.M605205200. PMID 17046823.