DVL3

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.[5][6]

DVL3
Identifiers
Aliases	DVL3, DRS3, dishevelled segment polarity protein 3
External IDs	OMIM: 601368 MGI: 108100 HomoloGene: 20928 GeneCards: DVL3
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 184,155,377 bp[1] End 184,173,614 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 12.46 cM Start 20,516,982 bp[2] End 20,534,010 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • Rac GTPase binding • beta-catenin binding • GO:0005110 frizzled binding • protease binding • GO:0001948 protein binding • protein heterodimerization activity • receptor binding Cellular component • cytoplasm • nuclear chromatin • cytosol Biological process • positive regulation of protein phosphorylation • GO:0007243 intracellular signal transduction • positive regulation of JUN kinase activity • protein stabilization • regulation of cellular protein localization • Wnt signaling pathway • positive regulation of transcription, DNA-templated • multicellular organism development • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • negative regulation of canonical Wnt signaling pathway • response to drug • beta-catenin destruction complex disassembly • non-canonical Wnt signaling pathway • non-canonical Wnt signaling pathway via JNK cascade • canonical Wnt signaling pathway • Wnt signaling pathway, planar cell polarity pathway • planar cell polarity pathway involved in neural tube closure • positive regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1857	13544
Ensembl	ENSG00000161202	ENSMUSG00000003233
UniProt	Q92997	Q61062
RefSeq (mRNA)	NM_004423	NM_007889 NM_001347176
RefSeq (protein)	NP_004414	NP_001334105 NP_031915
Location (UCSC)	Chr 3: 184.16 – 184.17 Mb	Chr 16: 20.52 – 20.53 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.[6]

Interactions

DVL3 has been shown to interact with DAB2,[7] DVL1[8] and PRPF3.[9]

See also

• Dishevelled

References

1. GRCh38: Ensembl release 89: ENSG00000161202 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003233 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–958. doi:10.1093/hmg/5.7.953. PMID 8817329.
6. "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)".
7. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. England. 22 (12): 3084–3094. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
8. Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. UNITED STATES. 19 (6): 4414–4422. doi:10.1128/mcb.19.6.4414. ISSN 0270-7306. PMC 104400. PMID 10330181.
9. Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–329, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Semënov MV, Snyder M (1997). "Human dishevelled genes constitute a DHR-containing multigene family". Genomics. 42 (2): 302–310. doi:10.1006/geno.1997.4713. PMID 9192851.
• Bui TD, Beier DR, Jonssen M, et al. (1997). "cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas". Biochem. Biophys. Res. Commun. 239 (2): 510–516. doi:10.1006/bbrc.1997.7500. PMID 9344861.
• Kishida S, Yamamoto H, Hino S, et al. (1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6): 4414–4422. doi:10.1128/mcb.19.6.4414. PMC 104400. PMID 10330181.
• Song DH, Sussman DJ, Seldin DC (2000). "Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells". J. Biol. Chem. 275 (31): 23790–23797. doi:10.1074/jbc.M909107199. PMID 10806215.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hocevar BA, Mou F, Rennolds JL, et al. (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–3094. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Torban E, Wang HJ, Groulx N, Gros P (2005). "Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family". J. Biol. Chem. 279 (50): 52703–52713. doi:10.1074/jbc.M408675200. PMID 15456783.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Chan DW, Chan CY, Yam JW, et al. (2006). "Prickle-1 negatively regulates Wnt/beta-catenin pathway by promoting Dishevelled ubiquitination/degradation in liver cancer". Gastroenterology. 131 (4): 1218–1227. doi:10.1053/j.gastro.2006.07.020. PMID 17030191.