DPYSL3

Dihydropyrimidinase-related protein 3 is an enzyme that in humans is encoded by the DPYSL3 gene.[5][6][7]

DPYSL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKN, 4CNS, 4CNT, 4CNU
Identifiers
Aliases	DPYSL3, CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1, dihydropyrimidinase like 3
External IDs	OMIM: 601168 MGI: 1349762 HomoloGene: 20361 GeneCards: DPYSL3
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 147,390,808 bp[1] End 147,510,068 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 43,320,984 bp[2] End 43,438,286 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SH3 domain binding • GO:0001948 protein binding • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds • chondroitin sulfate binding • hydrolase activity • filamin binding Cellular component • cytoplasm • cell body • filamentous actin • cytosol • cell projection • exocytic vesicle • growth cone • lamellipodium • extracellular • synapse Biological process • negative regulation of neuron projection development • regulation of cell migration • regulation of neuron projection development • neuron development • actin filament bundle assembly • negative regulation of cell migration • response to axon injury • actin crosslink formation • positive regulation of neuron projection development • protein homooligomerization • positive regulation of filopodium assembly • cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1809	22240
Ensembl	ENSG00000113657	ENSMUSG00000024501
UniProt	Q14195	Q62188
RefSeq (mRNA)	NM_001197294 NM_001387	NM_001136086 NM_001291455 NM_009468
RefSeq (protein)	NP_001184223 NP_001378	NP_001129558 NP_001278384 NP_033494
Location (UCSC)	Chr 5: 147.39 – 147.51 Mb	Chr 18: 43.32 – 43.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000113657 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024501 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
6. Gaetano C, Matsuo T, Thiele CJ (Jun 1997). "Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells". J Biol Chem. 272 (18): 12195–201. doi:10.1074/jbc.272.18.12195. PMID 9115293.
7. "Entrez Gene: DPYSL3 dihydropyrimidinase-like 3".

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Inagaki H, Kato Y, Hamajima N, et al. (2000). "Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system". Histochem. Cell Biol. 113 (1): 37–41. doi:10.1007/s004180050005. PMID 10664068.
• Matsuo T, Stauffer JK, Walker RL, et al. (2000). "Structure and promoter analysis of the human unc-33-like phosphoprotein gene. E-box required for maximal expression in neuroblastoma and myoblasts". J. Biol. Chem. 275 (22): 16560–8. doi:10.1074/jbc.M001312200. PMID 10748015.
• Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643.
• Weitzdoerfer R, Fountoulakis M, Lubec G (2002). Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. J. Neural Transm. Suppl. pp. 95–107. doi:10.1007/978-3-7091-6262-0_8. ISBN 978-3-211-83704-7. PMID 11771764.
• Franken S, Junghans U, Rosslenbroich V, et al. (2003). "Collapsin response mediator proteins of neonatal rat brain interact with chondroitin sulfate". J. Biol. Chem. 278 (5): 3241–50. doi:10.1074/jbc.M210181200. PMID 12444086.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rosslenbroich V, Dai L, Franken S, et al. (2003). "Subcellular localization of collapsin response mediator proteins to lipid rafts". Biochem. Biophys. Res. Commun. 305 (2): 392–9. doi:10.1016/S0006-291X(03)00754-X. PMID 12745088.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Choi YL, Kim CJ, Matsuo T, et al. (2005). "HUlip, a human homologue of unc-33-like phosphoprotein of Caenorhabditis elegans; Immunohistochemical localization in the developing human brain and patterns of expression in nervous system tumors". J. Neurooncol. 73 (1): 19–27. doi:10.1007/s11060-004-3013-3. PMID 15933812.
• Cole AR, Causeret F, Yadirgi G, et al. (2006). "Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo". J. Biol. Chem. 281 (24): 16591–8. doi:10.1074/jbc.M513344200. PMC 1805471. PMID 16611631.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.