DOK4

Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.[5][6]

DOK4
Identifiers
Aliases	DOK4, IRS-5, IRS5, docking protein 4
External IDs	OMIM: 608333 MGI: 2148865 HomoloGene: 10009 GeneCards: DOK4
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,471,922 bp[1] End 57,487,327 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 94,863,828 bp[2] End 94,876,330 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytosol Biological process • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55715	114255
Ensembl	ENSG00000125170	ENSMUSG00000040631
UniProt	Q8TEW6	Q99KE3
RefSeq (mRNA)	NM_018110 NM_001330556	NM_053246
RefSeq (protein)	NP_001317485 NP_060580 NP_001356547 NP_001356548 NP_001356549 NP_001356550	NP_444476
Location (UCSC)	Chr 16: 57.47 – 57.49 Mb	Chr 8: 94.86 – 94.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000125170 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040631 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
6. "Entrez Gene: DOK4 docking protein 4".

Further reading

• Al-Sarraf N, Reiff JN, Hinrichsen J, et al. (2007). "DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma". Int. J. Cancer. 121 (5): 992–8. doi:10.1002/ijc.22776. PMID 17443497.
• Uchida M, Enomoto A, Fukuda T, et al. (2007). "Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase". J. Cell Sci. 119 (Pt 15): 3067–77. doi:10.1242/jcs.03043. PMID 16820412.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cai D, Dhe-Paganon S, Melendez PA, et al. (2003). "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5". J. Biol. Chem. 278 (28): 25323–30. doi:10.1074/jbc.M212430200. PMID 12730241.
• Favre C, Gérard A, Clauzier E, et al. (2003). "DOK4 and DOK5: new Dok-related genes expressed in human T cells". Genes Immun. 4 (1): 40–5. doi:10.1038/sj.gene.6363891. PMID 12595900.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimm J, Sachs M, Britsch S, et al. (2001). "Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation" (PDF). J. Cell Biol. 154 (2): 345–54. doi:10.1083/jcb.200102032. PMC 2150770. PMID 11470823.